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. 2022 Sep 21;15(10):1169. doi: 10.3390/ph15101169

Table 1.

Summary of anti-HIV triterpenoids and their targets and activities.

Compounds IC50 EC50 Targets References
1 - - Entry inhibitors [16]
8 57.7 μM
30.3 μM
- Protease inhibitors
Integrase inhibitors
[46]
[45]
10 8 μM - Protease inhibitors [28]
35 μM - Integrase inhibitors [45]
11 13 μM - Protease inhibitors [28]
13 - - Protease inhibitors [30]
16 24.8 μM - Integrase inhibitors [45]
17 17.7 μM - Integrase inhibitors [45]
18 11.6 μM - Reverse transcriptase inhibitor [36]
19 0.03 μM - Maturation inhibitors [44]
20 0.02 μM - - [44]
21 4.08 μM - Replication inhibition [52]
22 4.18 μM - Replication inhibitors [52]
23 1.70 μM - Replication inhibitors [52]
34 >1.0 mM - Protease inhibitors [47]
35 7.8 μg/mL - Protease inhibitors [48]
40 30 μM - Protease inhibitors [48]
41 48 μM - Protease inhibitors [48]
42 25 μM - Protease inhibitors [48]
43 - 20.69 μg/mL - [32]
44 - 16.6 μg/mL - [32]
45 - 16.2 μg/mL - [32]
46 - 10.3 μg/mL - [32]
15.79 μM - Protease inhibitors [35]
47 20.44 μM - Protease inhibitors [35]
48 - 6.1 μg/mL - [33]
50 - 1.4 μg/mL - [34]
53 - 1.24 μM - [53]
54 - - - [54]