Table 3.
Distribution of PD-1 SNPs genotypes and allele frequencies in colorectal cancer cases and a control population.
| Locus | Model | Genotype | CRC (%) n = 100 |
Controls (%) n = 100 |
OR (95% CI) | p-Value | AIC |
|---|---|---|---|---|---|---|---|
| Rs10204525 G > A |
Alleles | G | 0.81 | 0.91 | 1 | ||
| A | 0.19 | 0.09 | 2.35 (1.24–4.03) | 0.00657 | |||
| Codominant | GG | 71 (71%) | 81 (81%) | 1.00 | |||
| GA | 20 (20%) | 19 (19%) | 1.20 (0.59–2.43) | 270.1 | |||
| AA | 9 (9%) | 0 (0%) | 21.65 (1.23–378.73) | 0.0014 | |||
| Dominant | GG | 71 (71%) | 81 (81%) | 1.00 | |||
| GA + AA | 29 (29%) | 19 (19%) | 1.74 (0.90–3.37) | 0.097 | 278.5 | ||
| Recessive | GA + GG | 91 (91%) | 100 (100%) | 1.00 | |||
| AA | 9 (9%) | 0 (0%) | 10.97 (1.37–87.43) | 0.0015 | 268.4 | ||
| Over-Dominant | GG + AA | 80 (80%) | 81 (81%) | 1.00 | |||
| GA | 20 (20%) | 19 (19%) | 1.07 (0.53–2.15) | 0.86 | 281.2 | ||
| Log-Additive | 1.98 (1.14–3.45) | 0.012 | 274.9 | ||||
| Rs2227981 A > G |
Alleles | A | 0.67 | 0.72 | Ref | - | |
| G | 0.33 | 0.28 | 0.79 (0.43–1.11) | 0.53 | |||
| Codominant | AA | 52 (52%) | 52 (52%) | 1.00 | 1 | 277.9 | |
| AG | 30 (30%) | 40 (40%) | 0.75 (0.41–1.38) | ||||
| GG | 18 (18%) | 8 (8%) | 2.25 (0.90–5.63) | 0.078 | |||
| Dominant | AA | 52 (52%) | 52 (52%) | 1.00 | |||
| AG + GG | 48 (48%) | 48 (48%) | 1.00 (0.57–1.74) | 1 | 281.3 | ||
| Recessive | AG + AA | 82 (82%) | 92 (92%) | 1.00 | |||
| GG | 18 (18%) | 8 (8%) | 2.52 (1.04–6.11) | 0.034 | 276.7 | ||
| Over-Dominant | AA-GG | 70 (70%) | 60 (60%) | 1.00 | 0.14 | 279.1 | |
| AG | 30 (30%) | 40 (40%) | 0.64 (0.36–1.15) | ||||
| Log-Additive | 1.22 (0.82–1.82) | 0.32 | 280.3 | ||||
| Rs2227982 G > A |
Alleles | G | 0.66 | 0.68 | 1 | ||
| A | 0.34 | 0.32 | 0.93 (0.61–1.41) | 0.83 | |||
| Codominant | GG | 38 (38%) | 40 (40%) | 1.00 | |||
| AG | 57 (57%) | 56 (56%) | 1.07 (0.60–1.91) | 0.92 | 283.1 | ||
| AA | 5 (5%) | 4 (4%) | 1.32 (0.33–5.27) | ||||
| Dominant | GG | 38 (38%) | 40 (40%) | 1.00 | |||
| AG+ AA | 62 (62%) | 60 (60%) | 1.09 (0.62–1.92) | 0.77 | 281.2 | ||
| Recessive | GG+ AG | 95 (95%) | 96 (96%) | 1.00 | |||
| AA | 5 (5%) | 4 (4%) | 1.26 (0.33–4.85) | 0.73 | 281.1 | ||
| Over-Dominant | AA +GG | 43 (43%) | 44 (44%) | 1.00 | |||
| AG | 57 (57%) | 56 (56%) | 1.04 (0.60–1.82) | 0.89 | 281.2 | ||
| Log-Additive | --- | --- | 1.10 (0.67–1.80) | 0.71 |
CRC: colorectal cancer, OR: odds ratio, 95% CI: 95% confidence interval, p < 0.05 was considered significant and these results are depicted in bold.