. 2022 Oct 13;58(10):1439. doi: 10.3390/medicina58101439

Table 5.

Association of PD-1 SNP polymorphisms with CRC after gender stratification.

Locus	Model	Genotype	CRC Female n = 36	CRC Male n = 64	OR (95% CI)	p-Value	AIC
Rs10204525	Allele	G	0.82	0.8	1
	Allele	A	0.18	0.2	1.102 (0.524–2.315)	0.79
	Codominant	GG	25 (69.4%)	46 (71.9%)	1
		GA	9 (25%)	11 (17.2%)	0.66 (0.24–1.82)	0.47	135.2
		AA	2 (5.6%)	7 (10.9%)	1.90 (0.37–9.86)
	Dominant	GG	25 (69.4%)	46 (71.9%)	1
	Dominant	GA-AA	11 (30.6%)	18 (28.1%)	0.89(0.36–2.18)	0.8	134.6
	Recessive	GG-GA	34 (94.4%)	57 (89%)	1
	Recessive	AA	2 (5.6%)	7 (10.9%)	2.09 (0.41–10.63)	0.35	133.8
	Over-Dominant	GG-AA	27 (75%)	53 (82.8%)	1
	Over-Dominant	GA	9 (25%)	11 (17.2%)	0.62 (0.23–1.68)	0.35	133.8
	Log-Additive	---	---	---	1.07 (0.57–2.04)	0.83	134.6
Rs2227981 A/G	Allele	A	0.6	0.71	Ref		-
	Allele	G	0.4	0.29	0.603 (0.329–1.106)	0.10
	Codominant	AA	16 (44.4%)	36 (56.2%)	1	0.35	134.6
		AG	11 (30.6%)	19 (29.7%)	0.77 (0.30–1.98)
		GG	9 (25%)	9 (14.1%)	0.44 (0.15–1.33)
	Dominant	AA	16 (44.4%)	36 (56.2%)	1	0.26	133.4
	Dominant	AG-GG	20 (55.6%)	28 (43.8%)	0.62 (0.27–1.42)
	Recessive	AA-AG	27 (75%)	55 (85.9%)	1	0.18	132.9
	Recessive	GG	9 (25%)	9 (14.1%)	0.49 (0.17–1.38)
	Over-Dominant	AA-GG	25 (69.4%)	45 (70.3%)	1	0.93	134.7
	Over-Dominant	AG	11 (30.6%)	19 (29.7%)	0.96 (0.39–2.33)
	Log-Additive	---	---	---	0.68 (0.40–1.16)	0.16	132.7
Rs2227982	Allele	G	0.67	0.66	Ref
	Allele	A	0.33	0.34	1.012 (0.549–1.866)	0.970
	Codominant	GG	13(36.1%)	25 (39.1%)	1
		AG	22 (61.1%)	35 (54.7%)	0.83 (0.35–1.95)	0.66	135.9
		AA	1 (2.8%)	4 (6.2%)	2.08 (0.21–20.57)
	Dominant	GG	13(36.1%)	25 (39.1%)	1
	Dominant	AG-AA	23 (63.9%)	39(60.9%)	0.88 (0.38–2.05)	0.77	134.6
	Recessive	GG-AG	35 (97.2%)	60 (93.8%)	1
	Recessive	AA	1 (2.8%)	4 (6.2%)	2.33 (0.25–21.71)	0.42	134
	Over-Dominant	GG-AA	14 (38.9%)	29 (45.3%)	1
	Over-Dominant	AG	22 (61.1%)	35 (54.7%)	0.77 (0.33–1.76)	0.53	134.3
	Log-Additive	---	---	---	1.02 (0.49–2.09)	0.96	134.7