Table 2. Antibacterial Activity of Focused Library 2 (Figure 4) Measured as the Minimum Inhibitory Concentration (MIC).
| 12 | 12a | 12b | 12c | 12d | 12e | 12f | 12g | 13 | 13a | 13b | 13c | 13d | 13e | 13f | 13g | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| methicillin-sensitive S. aureus (ATCC 12600) | 16 | 16 | 8 | 32 | 64 | >64a | 8 | 32 | 16 | 8 | 8 | 16 | 32 | 16 | 32 | >64a |
| methicillin-resistant S. aureus (ATCC 43300) | 32 | 16 | 8 | 32 | 32 | >64a | 8 | 32 | 16 | 8 | 8 | 16 | 32 | 16 | 16 | >64 |
| methicillin-resistant S. aureus (USA 300) | 16 | 16 | 8 | 32 | 32 | >64a | 8 | 32 | 8 | 8 | 8 | 16 | 16 | 16 | 16 | >64 |
a
Testing concentrations higher than 64 μg/mL were not used due to compound solubility limitations.