Table 2.
Effects of baseline factors on subsequent clinical outcomes. Interaction terms are listed in order of F values for main effect, with interaction terms having the greatest F value listed first
| B (95% CI) | p | |
|---|---|---|
| Outcome: CHOP INTEND | ||
| Time (months) | 0.090 (−0.189, 0.368) | 0.521 |
| Younger age | 10.76 (−0.60, 22.11) | 0.061 |
| Female | −0.338 (−7.194, 6.518) | 0.917 |
| Baseline CHOP INTEND | 0.536 (−0.116, 1.188) | 0.095 |
| Baseline Zlog10(IL-8) | −5.396 (−13.662, 2.870) | 0.176 |
| Baseline Zlog10(NfL) | −3.726 (−8.265, 0.812) | 0.097 |
| Younger age × Zlog10(IL-8) × Time | 0.767 (0.407, 1.126) | < 0.001 |
| Older age × Zlog10(IL-8) × Time | −0.421 (−0.939, 0.095) | 0.107 |
| Female × Younger age × Time | 1.088 (0.689, 1.488) | < 0.001 |
| Male × Younger age × Time | 0.281 (−0.133, 0.696) | 0.178 |
| Female × Older age × Time | −0.108 (−0.537, 0.320) | 0.614 |
| Male × Older age × Time | Reference | |
| Outcome: CMAPAPB | ||
| Time (months) | 0.049 (0.016, 0.083) | 0.005 |
| Younger age | 0.235 (−0.081, 0.551) | 0.140 |
| Baseline CMAPAPB | 0.887 (0.589, 1.186) | < 0.001 |
| Baseline Zlog10(IL-8) | 0.005 (−0.242, 0.251) | 0.969 |
| Baseline Zlog10(IL-8) × Time | −0.067 (−0.097, −0.036) | < 0.001 |
| Baseline CMAPAPB × Time | −0.117 (−0.182, −0.052) | < 0.001 |
| Female × Younger age × Time | 0.078 (0.033, 0.124) | 0.001 |
| Male × Younger age × Time | 0.109 (0.064, 0.154) | < 0.001 |
| Female × Older age × Time | 0.134 (0.032, 0.235) | 0.011 |
| Male × Older age × Time | Reference | |
| Outcome: weight Z-score | ||
| Time (months) | 0.111 (0.062, 0.159) | < 0.001 |
| Younger age | −1.275 (−2.454, −0.096) | 0.035 |
| Baseline Weight Z-score | 1.180 (1.030, 1.330) | < 0.001 |
| Baseline Zlog10(NfL) | 0.558 (−0.343, 1.460) | 0.220 |
| Younger age × Time | 0.114 (0.048, 0.180) | < 0.001 |
| Older age × Time | Reference | |
| Zlog10(NfL) × Time | −0.076 (−0.126, −0.027) | 0.003 |