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. 2022 Oct 26;611(7935):352–357. doi: 10.1038/s41586-022-05371-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Each point represents a pair of memory cells from different donors. Heavy and light chain edit distances are plotted, using the amino acids starting at the end of the leader and continuing through the last amino acid in the J segment. Points with identical coordinates are combined by showing a large point whose area is proportional to the number of such points. a, Cell pairs are displayed if the two cells in the pair have the same CDRH3 amino acid sequence. To increase readability, only one third of such pairs were selected at random for display. Of the pairs, 78% have light chain edit distance ≤ 20. This number (78%) is the fraction of cell pairs lying below the horizontal line at light chain edit distance 20, and was computed separately. It is proportional to the fraction of red below the line, if overlap is taken into account. b, [control] The same number of cell pairs were selected at random for display, without regard to CDRH3. Of the pairs, 9% have light chain edit distance ≤ 20.