Table 2.
Light chain coherence in complex antibody junctions
| Minimum CDRH3 amino acid identity | ||||||
|---|---|---|---|---|---|---|
| 100% | 90% | 80% | ||||
| No. of inserted bases in junction | Cell pairs | LCC (%) | Cell pairs | LCC (%) | Cell pairs | LCC (%) |
| 0 | 4,307 | 80.1 | 18,123 | 71.5 | 109,751 | 58.0 |
| 1 | 188 | 97.3 | 1,616 | 95.0 | 10,044 | 75.3 |
| 2 | 134 | 84.3 | 1,626 | 86.3 | 16,704 | 85.4 |
| 3 | 21 | 85.7 | 449 | 65.0 | 4,808 | 54.2 |
| 4 | 7 | 100.0 | 74 | 89.2 | 1,839 | 63.5 |
| 5 | 0 | 34 | 82.4 | 1,012 | 71.2 | |
| 6 | 0 | 64 | 81.2 | 1,176 | 68.8 | |
| 7 | 0 | 60 | 95.0 | 826 | 82.2 | |
| ≥ 8 | 18 | 100.0 | 80 | 90.0 | 656 | 67.5 |