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. 2022 Oct 26;611(7935):352–357. doi: 10.1038/s41586-022-05371-z

Table 2.

Light chain coherence in complex antibody junctions

Minimum CDRH3 amino acid identity
100% 90% 80%
No. of inserted bases in junction Cell pairs LCC (%) Cell pairs LCC (%) Cell pairs LCC (%)
0 4,307 80.1 18,123 71.5 109,751 58.0
1 188 97.3 1,616 95.0 10,044 75.3
2 134 84.3 1,626 86.3 16,704 85.4
3 21 85.7 449 65.0 4,808 54.2
4 7 100.0 74 89.2 1,839 63.5
5 0 34 82.4 1,012 71.2
6 0 64 81.2 1,176 68.8
7 0 60 95.0 826 82.2
≥ 8 18 100.0 80 90.0 656 67.5

For pairs of memory cells as in Fig. 1, using varying CDRH3 amino acid identity we show the light chain coherence (LCC) as a function of the number of inserted bases in the junction sequence (see also Fig. 3).