FIG. 1.

Dose-response inhibition of IL-1β, TNF-α, IL-6, and IFN-γ production (A) and of MCP-1, MIP-1α, and MIP-1β production (B) by PBMC stimulated with 150 ng of SEB/ml in the presence of various D609 concentrations. Values represent means ± standard errors of the means for duplicate samples from two experiments. Inhibition at all concentrations of D609, with the exception of 0.01 mM, was statistically significant by comparison to control SEB-stimulated cells (P < 0.02).