TABLE 1.
Identified differentially expressed metabolites between HGWD-treated and control groups of mice (negative ion).
| Metabolite | Rt (s) | m/z | VIP | Fold change (FC) | p-value |
|---|---|---|---|---|---|
| 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine | 138.47 | 794.57 | 2.27 | 0.72 | 0.0001 |
| Pc(18:1e/14,15-eet) | 38.92 | 868.60 | 1.75 | 0.52 | 0.0004 |
| Daidzein 4′-sulfate | 25.81 | 333.01 | 3.07 | 0.20 | 0.0009 |
| Palmitic acid | 50.47 | 255.23 | 12.34 | 1.43 | 0.0010 |
| Myristic acid | 51.10 | 227.20 | 5.54 | 2.93 | 0.0011 |
| Dodecanoic acid | 52.32 | 199.17 | 2.47 | 2.38 | 0.0022 |
| 7Z, 10Z, 13Z, 16Z, 19Z-Docosapentaenoic acid | 47.68 | 329.25 | 2.44 | 2.06 | 0.0026 |
| Octadecanoic acid | 49.59 | 283.26 | 5.34 | 1.39 | 0.0035 |
| Pc(16:0e/5,6-eet) | 55.61 | 842.59 | 1.78 | 0.38 | 0.0036 |
| 6-hydroxyhexanoate | 131.80 | 131.07 | 2.75 | 2.53 | 0.0043 |
| Cis-9-palmitoleic acid | 49.80 | 253.22 | 5.83 | 2.18 | 0.0045 |
| Indolelactic acid | 34.01 | 158.06 | 1.13 | 0.42 | 0.0057 |
| Pe (18:1e/10-hdohe) | 38.61 | 790.54 | 3.08 | 0.62 | 0.0062 |
| Myristoleic acid | 51.06 | 225.19 | 2.09 | 2.95 | 0.0062 |
| Pantothenate | 279.60 | 218.10 | 1.68 | 0.50 | 0.0068 |
| 2-ketohexanoic acid | 37.02 | 129.06 | 1.47 | 0.56 | 0.0077 |
| d-proline | 315.24 | 114.06 | 1.23 | 0.56 | 0.0079 |
| Phenylalanine | 266.55 | 164.07 | 2.14 | 0.60 | 0.0082 |
| (2-aminoethoxy)[2-[docosa-4.7.10.13.16.19-hexaenoyloxy]-3-[octadeca-1.9-dien-1-yloxy]propoxy]phosphinic acid | 138.08 | 772.53 | 1.44 | 0.83 | 0.0082 |
| Eicosenoic acid | 47.82 | 309.28 | 2.14 | 2.00 | 0.0115 |
| Pe (18:1e/20-hdohe) | 140.86 | 790.54 | 3.95 | 0.74 | 0.0123 |
| Pseudouridine | 247.19 | 243.06 | 1.17 | 0.66 | 0.0149 |
| D-(+)-mannose | 117.83 | 179.03 | 1.63 | 0.25 | 0.0170 |
| Pentadecanoic acid | 50.51 | 241.22 | 1.04 | 1.52 | 0.0177 |
| Gly-His-Lys | 27.62 | 339.20 | 1.37 | 1.84 | 0.0178 |
| Glycocholic acid | 187.39 | 464.31 | 1.44 | 0.71 | 0.0189 |
| Pc(16:0e/8-hepe) | 140.44 | 840.58 | 2.36 | 0.75 | 0.0200 |
| 9R,10S-EpOME | 57.03 | 295.23 | 1.95 | 0.58 | 0.0207 |
| 12s-hydroxy-5z,8z,10e,14z-eicosatetraenoic acid | 54.39 | 319.23 | 2.85 | 3.23 | 0.0209 |
| Taurochenodeoxycholate | 162.68 | 498.29 | 3.38 | 0.30 | 0.0228 |
| 3-dehydrocholic acid | 147.27 | 405.26 | 1.61 | 2.77 | 0.0251 |
| 3-Hydroxydodecanoic acid | 92.45 | 215.16 | 1.23 | 3.70 | 0.0270 |
| Cis-4,7,10,13,16,19-docosahexaenoic acid | 48.82 | 327.23 | 5.40 | 1.83 | 0.0302 |
| Djenkolic acid | 25.26 | 253.05 | 2.59 | 0.18 | 0.0320 |
| Acetylglycine | 430.00 | 233.08 | 3.16 | 1.38 | 0.0345 |
| Pi 36:4 | 196.77 | 857.52 | 7.16 | 0.58 | 0.0375 |
| Pc(18:1e/20-hdohe) | 137.33 | 892.60 | 1.43 | 0.79 | 0.0402 |
| Deoxycholic acid | 160.21 | 391.28 | 1.50 | 1.78 | 0.0411 |
| Humulone | 178.01 | 361.20 | 1.32 | 3.50 | 0.0420 |
| Hydroquinidine | 28.01 | 325.18 | 1.16 | 1.72 | 0.0433 |
| 1-palmitoyl-2-oleoyl-phosphatidylglycerol | 38.26 | 747.52 | 1.68 | 0.78 | 0.0449 |
| 3-hydroxycapric acid | 106.62 | 187.13 | 1.15 | 1.83 | 0.0471 |