Table 2.
Antifungal activity of chalcone and its derivatives [66].
| No. | Materials Tested Drug |
Test Assay | Antifungal Strains (MIC μg/mL) | Standard Antifungal | Antifungal Effect | |
|---|---|---|---|---|---|---|
| A. niger | C. albicans | |||||
| 61 | 1,3-Bis(4-chlorophenyl)-3-(phenylsulfonyl)propan-1-one | BMD | 15.62 | 31.25 | AMP-B, NSN | Very strong |
| 62 | 1-Phenyl-3-(4-chlorophenyl)-3-(phenylsulfonyl)propane-1-one | BMD | 125 | 1.95 | AMP-B, NSN | Very strong |
| 63 | 1-(4-Chlorophenyl)-3-(3-nitrophenyl)-3-phenylsulfonylprop-ane-1-one | BMD | 62.5 | 1.95 | AMP-B, NSN | Very strong |
| 64 | 1-(4-Bromophenyl)-3-phenyl-3-(phenylsulfonyl) propane-1-one | BMD | 62.5 | 125 | AMP-B, NSN | Very strong |
| 65 | 1-(4-Bromophenyl)-3-(3,4-dimethoxyphenyl)-3-(phenylsulfonyl)propane-1-one | BMD | 15.62 | 15.62 | AMP-B, NSN | Very strong |
| 66 | 1-(4-Bromophenyl)-3-(3,4,5-trimethoxyphenyl)-3-(phenylsulfonyl) propane-1-one | BMD | 7.81 | 3.9 | AMP-B, NSN | Very strong |
| 67 | 1-Phenyl-3-phenyl- 3-phenylsulfonylpropane-1-one | BMD | 7.81 | 3.9 | AMP-B, NSN | Very strong |
| 68 | 1,5-Di(4-methylphenyl)-1,5-bis(phenylsulfonyl)pentan-3-one | BMD | 31.25 | 1.95 | AMP-B, NSN | Very strong |
| 69 | 1,5-Di(4-chlorophenyl)-1,5-bis(phenylsulfonyl)pentan-3-one | BMD | 125 | 1.95 | AMP-B, NSN | Very strong |
| 70 | 1,5-Di(phenyl)-1,5-bis(phenylsulfonyl)pentan-3-one | BMD | 125 | 250 | AMP-B, NSN | Strong |
| 71 | 1,5-Di(4-methoxyphenyl)-1,5-bis(phenylsulfonyl)pentan-3-one | BMD | 125 | 125 | AMP-B, NSN | Strong |
BMD: Broth microdilution; AMP: Amphotericin-B (MIC: 500 μg/mL for A. niger, 15.62 μg/mL for C. albicans), NSN: Nystatin (MIC: 7.81 μg/mL for A. niger and C. albicans).