Table 4.

Association between the low-dose of alteplase and the risk of sICH

	Unadjusted (OR, 95%CI)	p-value	Age- sex- adjusted (OR, 95%CI)	p-value	Multivariable	p-value
Age (continuous)	1.07 (1.03-1.10)	0.001	/	/	1.06 (1.01-1.11)	0.016
Female sex	1.50 (0.74-3.02)	0.261	/	/	0.81 (0.35-1.85)	0.614
Hyperlipidemia	0.44 (0.19-1.02)	0.056	0.51 (0.22-1.22)	0.129	0.55 (0.21-1.40)	0.206
Diabetes	2.03 (0.97-4.24)	0.060	1.80 (0.85-3.82)	0.125	1.09 (0.40-2.96)	0.878
Atrial fibrillation	6.79 (3.09-14.93)	<0.001	5.35 (2.40-11.94)	<0.001	3.20 (1.33-7. 70)	0.009
Baseline blood glucose (>10mmol/L)	2.52 (1.15 - 5.50)	0.021	2.70 (1.21 - 6.02)	0.015	1.93 (0.64 - 5.83)	0.245
Baseline NIHSS score	1.19 (1.12-1.26)	<0.001	1.18 (1.11-1.25)	<0.001	1.16 (1.08-1.24)	<0.001
Low-dose	0.251 (0.06-1.07)	0.02	0.17 (0.04-0.76)	0.02	0.13 (0.03-0.62)	0.010

Abbreviations: OR, Odds ratio; CI, confidence interval; NIHSS, national institute of health stroke scale.