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. 2022 Oct 19;26(6):358. doi: 10.3892/mmr.2022.12875

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Copyright: © Kim et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Expression of LCN2 is specifically induced in the colon tissue of DSS-induced colitis mice. (A) Macroscopic appearance of inflammation in the colon (upper panel). Body weight and colon length were statistically analyzed (lower panel). (B) Images of hematoxylin and eosin staining (magnification, ×10) of colonic mucosal tissue sections from mice were captured using microscopy. (C) Total tissue extracts were prepared after animal sacrifice and analyzed for LCN2 and actin antibody by western blotting. Actin was used as a loading control. (D) After homogenizing colonic tissues, level of LCN2 in tissues was detected using ELISA. (E) IHC images of LCN2 expression in the colonic tissues from control and colitis mice show positively bound cells in brown (magnification, ×20). **P<0.01, ***P<0.001. LCN2, lipocalin 2; DSS, dextran sulfate sodium; IHC, immunohistochemical.