Table 1.
Zebrafish orthologs of human genes mutated in FAD.
| Protein | Human Gene and Protein Length | Zebrafish Gene and Protein Length | Amino Acid Similarity | References |
|---|---|---|---|---|
| Amyloid Precursor Protein | APP | appa & appb | [36] | |
| APP Protein: 695 a.a. | Appa Protein: 738 a.a. | 74% | ||
| Appb Protein: 694 a.a. | 77% | |||
| β-secretase | BACE1 & BACE2 | bace1 & bace2 | [42] | |
| BACE1 Protein: 501 a.a. | Bace1 Protein: 505 a.a. | 82% | ||
| BACE2 Protein: 518 a.a. | Bace2 Protein: 462 a.a. | - | [43] | |
| γ-secretase | PSENEN | psenen | [44, 45] | |
| PSENEN Protein: 101 a.a. | Psenen Protein: 101 a.a. | 91% | ||
| NCSTN | ncstn | [46] | ||
| NCSTN Protein: 709 a.a. | Ncstn Protein: 707 a.a. | 56% | ||
| APH1b | aph1b | |||
| APH1b Protein: 257 a.a. | Aph1p Protein: 258 a.a. | - | ||
| Prensenilin-1 | PSEN1 | psen1 | [47] | |
| PSEN1 Protein: 456 a.a. | Psen1 Protein: 456 a.a. | 75% | ||
| Prensenilin-2 | PSEN2 | psen2 | [30] | |
| PSEN2 Protein: 456 a.a. | Psen2 Protein: 441 a.a. | 76% | ||
| Apolipoprotein E | APOE | apoea | [48, 49] | |
| APOE Protein: 317 a.a. | Apoea Protein: 269 a.a. | 49% | ||
| apoeb | ||||
| Apoeb Protein: 281 a.a. | 51% | |||
| Sortilin related receptor 1 | SORL1 | sorl1 | [50] | |
| SORL1 Protein: 2214 a.a. | Sorl1 Protein: 2213 a.a. | 64% | ||