Table IV.
Functions of proteins identified in control placenta.
| First author, year | Proteins | Functions | (Refs.) |
|---|---|---|---|
| Arimura Y, 2018 | Histone H2B type 2-F | Core component of nucleosome serves a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability | (44) |
| Pater D, 2021 | Alpha-1-antitrypsin | α1-antitrypsin is a protein belonging to the serpin superfamily | (45) |
| Xi Y, 2020 | Annexin A2 | Placental anticoagulant protein IV | (46) |
| Monceau V, 2004 | Annexin A5 | Is a cellular protein with presumed function of plasma membrane repair and hemostasis | (123) |
| Li A, 2021 | Actin, alpha cardiac muscle 1 | The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. | (124) |
| Yuan SM, 2018 | Actin, aortic smooth muscle | α-2 actin is found in smooth muscle cells, a family of globular multi-functional proteins that form microfilaments | (125) |
| Jonckheere A, 2012 | ATP synthase subunit beta, mitochondrial | Mitochondrial membrane ATP synthase [F(1)F(0) ATP synthase or Complex V] produces ATP from ADP in the presence of a proton gradient across the membrane | (126) |
| Männik J, 2012 | Chorionic somatomammotropin hormone 1 | Produced only during pregnancy and is involved in stimulating lactation, fetal growth and metabolism. | (127) |
| D'Acquisto F, 2008 | Annexin A1 | Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. | (47) |
| Peng W, 2021 | Alpha-actinin-4 | Alpha actinin is an actin-binding protein with multiple roles in different cell types. | (48) |
| Bays JL, 2017 | Vinculin | Vinculin is a cytoplasmic actin-binding protein enriched in focal adhesions and adherens junctions that is essential for embryonic development. | (128) |
| Patino MG, 2002 | Collagen alpha-1(XIV) chain | It likely serves a role in collagen binding and cell-cell adhesion. | (129) |
| Sudo H, 2013 | Neuroblast differentiation-associated protein | Protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation and tumor metastasis | (130) |
| Sun H, 2020 | Myosin-9 | Serves a role in cytokinesis, cell shape and specialized functions such as secretion and capping. During cell spreading, serves an important role in cytoskeleton reorganization, focal contact formation | (131) |
| Su W, 2012 | Filamin A | Filamins play multiple cellular roles, serving as organizers of cell structure (e.g., cytoskeleton) and function, regulating cell signaling, transcription, cell adhesion, focal adhesion assembly, cell apoptosis and organ development. | (132) |
| Burrudge K, 2018 | Talin | Probably involved in connections of major cytoskeletal structures to the plasma membrane. | (133) |