Table 1.
Pathogenicity and transmission of A/Hunan/42443/2015 A (H1N1v) virus in ferrets.
| Ferret groupa | Virus in NWb | Seroconversionc | % Weight lossd | Fever (°C)e | Nasal discharge | Sneezing | ||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| # ferrets | Virus titer | # ferrets | HI titer | |||||
|
| ||||||||
| Inoculated | 6/6 | 5.8 ± 0.8 | 6/6 | 320–2560 | 13.5 (6/6) | 1.5 (6/6) | 6/6 | 4/6 |
| Contact (DCT) | 3/3 | 5.9 ± 0.6 | 3/3 | 1280–2560 | 7.5 (3/3) | 1.2 (3/3) | 2/3 | 0/3 |
| Contact (RDT) | 2/3 | 6.2 ± 0.9 | 2/3 | 640–1280 | 11.6 (2/3) | 1.5 (2/3) | 1/3 | 0/3 |
Ferrets were intranasally inoculated or exposed to virus in a direct contact transmission (DCT) model or a respiratory droplet transmission (RDT) model.
Number of ferrets with detectable virus in nasal wash (NW) samples and mean peak titer (log10 PFU/ml) ± SD is shown.
Number of ferrets that seroconverted by day 20 (contact ferrets) and 21 (inoculated ferrets) to homologous virus in a hemagglutination inhibition (HI) assay.
Percentage mean maximum weight loss is shown with the number of ferrets displaying weight loss in parentheses.
Mean maximum rise in temperature relative to baseline (38.4–39.3 °C) is shown with the number of ferrets displaying fever in parentheses.