Table 3.
Univariable and multivariable analysis for predictors of local recurrence, regional recurrence, distant recurrence, and overall survival
| Local Recurrence | Regional Recurrence | Distant Recurrence | Overall Survival | |||||
|---|---|---|---|---|---|---|---|---|
|
|
||||||||
| Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | Univariable | Multivariable | |
|
|
||||||||
| Covariate | Hazard Ratio (95% CI), p-value | |||||||
|
| ||||||||
| Pathologic Stage | ||||||||
| Stage I-III | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Stage IV | 1.08 (.49–2.38), p= 0.86 | 0.54 (0.20, 1.41), p = 0.21 | 1.43 (0.58–3.51) p= 0.44 | 0.54 (0.17–1.69), p= 0.29 | 1.73 (0.76–3.90), p= 0.19 | 0.85 (0.33–2.21), p=0.73 | 2.33 (1.15–4.71), p< 0.01 | 1.19 (0.53–2.65), p=0.68 |
| Tumor size, mean | 1.19 (0.98–1.45), p= 0.09 | 1.24 (0.97, 1.60) p= 0.09 | 1.15 (0.92–1.44), p= 0.23 | 1.31 (0.99–1.72), p= 0.06 | 1.25 (1.04–1.50), p< 0.01 | 1.2 (0.96–1.49), p= 0.12 | 1.22 (1.06–1.42), p< 0.01 | 1.18 (0.99–1.41), p= 0.07 |
| Rapid Recurrence | 13.9 (5.96–32.5), p< 0.01 | 13.1 (5.55–31.1), p< 0.01 | 16.6 (6.47–42.8), p< 0.01 | 15.4 (5.77–41.2), p< 0.01 | 4.67 (2.23–9.78), p< 0.01 | 3.71 (1.75–7.88), p< 0.01 | 6.16 (3.41–11.1) p< 0.01 | 5.47 (3.01–9.97), p< 0.01 |
| ENE | ||||||||
| No | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Yes | 2.77 (1.25–6.15), p= 0.01 | 2.01 (0.77–5.26), p= 0.15 | 4.57 (1.97–10.6), p< 0.01 | 3.73 (1.32–10.6), p< 0.01 | 3.90 (1.86–8.19), p< 0.01 | 2.05 (0.83–5.07), p= 0.12 | 4.78 (2.64–8.67), p< 0.01 | 2.75 (1.36–5.54), p< 0.01 |
| PNI | ||||||||
| No | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Yes | 2.11 (0.97–4.61), p= 0.06 | 1.70 (0.75–3.82), p= 0.20 | 4.15 (1.62–10.6) p< 0.01 | 3.82 (1.43–10.2), p< 0.01 | 2.96 (1.38–6.39), p< 0.01 | 1.86 (0.84–4.15), p= 0.13 | 3.19 (1.68–5.80), p< 0.01 | 2.07 (1.09–3.93), p< 0.05 |
| LVI | ||||||||
| No | Reference | Reference | Reference | Reference | Reference | Reference | Reference | Reference |
| Yes | 1.87 (0.84–4.21) p= 0.13 | 1.03 (0.41–2.56), p= 0.95 | 1.05 (0.39–2.85) p= 0.92 | 0.43 (0.15–1.23), p= 0.12 | 3.93 (1.89–8.14) p< 0.01 | 1.89 (0.81–4.38), p= 0.14 | 2.80 (1.55–5.03) p< 0.01 | 1.15 (0.59–2.23), p=0.68 |
bold indicates p <0.05