Table 4.

Multivariable analysis for predictors of local recurrence, regional recurrence, distant recurrence, and overall survival (excluding oropharynx and salivary gland)

Covariate	Local Recurrence	Regional Recurrence	Distant Recurrene	Overall Survival
Pathologic Stage
Stage I-III	Reference	Reference	Reference	Reference
Stage IV	0.79, p= 0.67	1.32, p= 0.67	1.49, p= 0.54	1.52, p= 0.38
Tumor size, mean	1.15, p= 0.38	1.06, p= 0.76	1.17, p= 0.28	1.14, p= 0.25
Rapid Recurrence	14.7, p< 0.01	20.9, p< 0.01	6.30, p< 0.01	7.32, p< 0.01
ENE
No	Reference	Reference	Reference	Reference
Yes	2.47, p= 0.08	6.48, p< 0.01	3.22, p= 0.02	3.36, p< 0.01
PNI
No	Reference	Reference	Reference	Reference
Yes	1.59, p= 0.32	6.29, p< 0.01	1.60, p= 0.35	2.08, p= 0.06
LVI
No	Reference	Reference	Reference	Reference
Yes	0.95, p= 0.93	0.25, p= 0.02	1.13, p= 0.82	0.75, p= 0.48

bold indicates p <0.05