Table 2.
Overview of the RBE obtained via Equation (9) for the 28 survival curves in the function of absorbed dose discussed in Section 5.2. For each RBE, details are given about the radionuclide, the cell type, and the applied dosimetry (physical or effective decay for the Time Activity Constant (TAC), the cell geometry, and the target region). The results are averaged for beta, Auger, and alpha radiation, and the standard deviation is reported.
| Radionuclide | Cell Line | TAC | Cell Geometry | Target | RBEm | Ref. |
|---|---|---|---|---|---|---|
| I | CA20948 | sphere | entire cell | 1.2 | [36] | |
| Lu | U2OS + SSTR2 | realistic | nucleus | 1.7 | [31] | |
| Lu | U2OS + SSTR2 | sphere | nucleus | 0.5 | [19] | |
| Lu | CA20948 | sphere | nucleus | 3.5 | [19] | |
| Lu | CA20948 | sphere | entire cell | 0.4 | [37] | |
| Lu | Capan-2 | sphere | nucleus | 1 | [38] | |
| Lu | LNCaP | sphere | entire cell | 0.4 | [10] | |
| Lu | DU145 | sphere | entire cell | 1.5 | [10] | |
| Lu | PC3 | sphere | entire cell | 1.5 | [10] | |
| P | SCL-II | sphere | nucleus | 0.5 | [39] | |
| Y | HCT116 | sphere | nucleus | 0.2 | [14] | |
| Y | SW48 | sphere | nucleus | 0.2 | [14] | |
| Y | HT29 | sphere | nucleus | 0.2 | [14] | |
| Average RBE | 1.0 ± 0.9 | |||||
| I | PC Cl3 | sphere | nucleus | 3.4 | [32] | |
| I | PC Cl3 | sphere | cytoplasm | 1.7 | [32] | |
| I | PC Cl3 | sphere | entire cell | 1.9 | [32] | |
| Tc | PC Cl3 | sphere | nucleus | 2.2 | [32] | |
| Tc | PC Cl3 | sphere | cytoplasm | 0.7 | [32] | |
| Tc | PC Cl3 | sphere | entire cell | 0.8 | [32] | |
| I | SCL-II | sphere | nucleus | 4.5 | [39] | |
| Cu | MCF7/HER2-18 | sphere | nucleus | 0.6 | [40] | |
| Average RBE | 2.0 ± 1.3 | |||||
| Bi | CA20948 | sphere | entire cell | 2.7 | [37] | |
| Bi | CA20948 | sphere | entire cell | 3.5 | [37] | |
| Bi | Capan-2 | sphere | nucleus | 3.4 | [38] | |
| Am | LNCaP | sphere | entire cell | 8.1 | [10] | |
| Am | DU145 | sphere | entire cell | 15.2 | [10] | |
| Am | PC3 | sphere | entire cell | 14.0 | [10] | |
| Am | SW-1573 | sphere | nucleus | 14.7 | [41] | |
| Average RBE | 8.8 ± 5.3 | |||||