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. 2022 Sep 22;14(10):2007. doi: 10.3390/pharmaceutics14102007

Table 2.

Overview of the RBEm obtained via Equation (9) for the 28 survival curves in the function of absorbed dose discussed in Section 5.2. For each RBEm, details are given about the radionuclide, the cell type, and the applied dosimetry (physical or effective decay for the Time Activity Constant (TAC), the cell geometry, and the target region). The results are averaged for beta, Auger, and alpha radiation, and the standard deviation is reported.

Radionuclide Cell Line TAC Cell Geometry Target RBEm Ref.
131I CA20948 Teff sphere entire cell 1.2 [36]
177Lu U2OS + SSTR2 Teff realistic nucleus 1.7 [31]
177Lu U2OS + SSTR2 Teff sphere nucleus 0.5 [19]
177Lu CA20948 Teff sphere nucleus 3.5 [19]
177Lu CA20948 Tph sphere entire cell 0.4 [37]
177Lu Capan-2 Tph sphere nucleus 1 [38]
177Lu LNCaP Tph sphere entire cell 0.4 [10]
177Lu DU145 Tph sphere entire cell 1.5 [10]
177Lu PC3 Tph sphere entire cell 1.5 [10]
32P SCL-II Tph sphere nucleus 0.5 [39]
90Y HCT116 Tph sphere nucleus 0.2 [14]
90Y SW48 Tph sphere nucleus 0.2 [14]
90Y HT29 Tph sphere nucleus 0.2 [14]
Average RBEbeta 1.0 ± 0.9
123I PC Cl3 Teff sphere nucleus 3.4 [32]
123I PC Cl3 Teff sphere cytoplasm 1.7 [32]
123I PC Cl3 Teff sphere entire cell 1.9 [32]
99mTc PC Cl3 Teff sphere nucleus 2.2 [32]
99mTc PC Cl3 Teff sphere cytoplasm 0.7 [32]
99mTc PC Cl3 Teff sphere entire cell 0.8 [32]
125I SCL-II Tph sphere nucleus 4.5 [39]
64Cu MCF7/HER2-18 Teff sphere nucleus 0.6 [40]
Average RBEAuger 2.0 ± 1.3
213Bi CA20948 Tph sphere entire cell 2.7 [37]
213Bi CA20948 Tph sphere entire cell 3.5 [37]
213Bi Capan-2 Tph sphere nucleus 3.4 [38]
241Am LNCaP Tph sphere entire cell 8.1 [10]
241Am DU145 Tph sphere entire cell 15.2 [10]
241Am PC3 Tph sphere entire cell 14.0 [10]
241Am SW-1573 Tph sphere nucleus 14.7 [41]
Average RBEalpha 8.8 ± 5.3