Table 1.
Baseline characteristics of lupus nephritis patients of African descent versus Caucasians
| African descent (n=52) | Caucasian (n=85) | P value | |
| Age | 31.7 (±12) | 29.4 (±9.0) | 0.16 |
| Women | 50 (96%) | 75 (88%) | 0.13 |
| Diagnosis decade | |||
| <2000 | 1 (2%) | 19 (22%) | <0.001 |
| 2000–2010 | 13 (25%) | 41 (48%) | |
| >2010 | 38 (73%) | 25 (29%) | |
| Histological class | <0.001 | ||
| III±V (N; %) | 20 (38%) | 18 (21%) | |
| IV±V (N; %) | 19 (37%) | 61 (72%) | |
| V only (N; %) | 13 (25%) | 6 (7%) | |
| Biology | |||
| Anti-DNA antibodies | 45 (87%) | 56 (66%) | 0.004 |
| aPL antibodies | 10 (19%) | 14 (16%) | 0.72 |
| Initial immunosuppressive drug | <0.001 | ||
| CYC (N; %) | 19 (37%) | 63 (74%) | |
| MMF (N; %) | 25 (48%) | 15 (17%) | |
| Others (N; %) | 8 (15%) | 7 (8%) | |
| Other drugs | |||
| Intravenous MP (N; %) | 28 (54%) | 63 (74%) | 0.01 |
| HCQ (N; %) | 41 (79%) | 65 (77%) | 0.7 |
| Biological parameters | |||
| Creatinine (mg/dL) | 1.16 (±1.5) | 1.01 (± 0.5) | 0.39 |
| eGFR (mL/min/1.73 m²) | 93.9 (±40) | 95.0 (±41) | 0.87 |
| Serum C3 (g/L) | 0.64 (±0.3) | 0.62 (±0.3) | 0.8 |
| Serum C4 (g/L) | 0.12 (0.1) | 0.10 (0.05) | 0.1 |
| uP/C (g/g) | 3.53 (±5.2) | 3.27 (±2.7) | 0.7 |
Unless stated otherwise, values are mean±SD. P value <0.05 was considered statistically significant.
uP/C, urine protein to creatinine ratio.aPL, anti-phospholipid; CYC, cyclophosphamide; eGFR, estimated glomerular filtration rate; HCQ, hydroxychloroquine; MMF, mycophenolate mofetil; MP, methylprednisolone.