Figure 1.

Following bariatric-surgery-induced weight loss, visceral adipose tissue deposits are decreased, as well as renal sinus fat deposits. The decrease in the former contributes to a favorable adipocytokine profile, reduction in inflammatory cytokines, and reduction in ROS production, while the latter might lead to a less-activated RAAS. Decreased total renal blood flow has also been described following bariatric-surgery-induced weight loss. Clinically, following bariatric surgery, the glomerular filtration rate is decreased in patients with glomerular hyperfiltration and increased in patients who already have a more advanced stage of chronic kidney disease. In both stages, albuminuria is decreased. These favorable outcomes ultimately decrease the rate of progression towards a more advanced stage of chronic kidney disease.