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. 2022 Sep 26;14(10):2044. doi: 10.3390/pharmaceutics14102044

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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NIL10 induces cardiac protection in mice subjected to IR. (A) Graphical view of the procedures performed. (B) Representative electrocardiogram, showing ST-elevation after LAD occlusion. (C) Left ventricle ejection fraction (LVEF) of wild-type mouse hearts at the times indicated after IR and injected with NIL10 or NIL10SC as in A. n = 10 mice/group. Results are expressed as mean ± SD. * p < 0.03 NIL10 vs. NIL10SC day 7. # p < 0.05 NIL10 vs. NIL10SC day 3. (D) LVEF in IL-10 knockout mice. n = 10 mice/group. Results are expressed as mean ± SD. * p < 0.01 NIL10 vs. NIL10SC day 7. # p < 0.05 NIL10 vs. NIL10SC day 3. (E) LVEF in IL-10 receptor knockout mice. n = 10 mice/group. Results are expressed as mean ± SD.