Table 2:
CMV multivariate regression models for blood donors, organ donors, and recipients
| Odds ratio (95% CI) | ||||
|---|---|---|---|---|
| Variable | Blood donor | Adult organ donor | Adult recipient | Pediatric recipient |
| Age | 1.021 (1.021 to 1.022)* | 1.02 (1.01 to 1.03)* | 1.03 (1.03 to 1.04)* | 1.05 (1.00 to 1.10) |
| Sex | ||||
| Male | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) | 1 (Ref.) |
| Female | 0.96 (0.94 to 0.98)* | 1.47 (1.26 to 1.73)* | 1.53 (1.33 to 1.76)* | 1.66 (1.04 to 2.66)† |
| Age × Female | 1.0053 (1.0047 to 1.0058)* | — | — | — |
| Organ‡ | ||||
| Kidney | — | — | 1.00 (Ref.) | 1.00 (Ref.) |
| Liver | — | — | 1.38 (1.17 to 1.62)* | 1.31 (0.71 to 2.43) |
| Heart | — | — | 0.95 (0.78 to 1.16) | 2.64 (1.44 to 4.91)§ |
| Lung | — | — | 0.92 (0.75 to 1.12) | 0.54 (0.08 to 2.56) |
| Period | ||||
| 1984–1998 | — | — | 1 (Ref.) | — |
| 1999–2013 | — | — | 0.70 (0.60 to 0.81)† | — |
| Region | ||||
| BC and Yukon | 1.00 (Ref.) | — | — | — |
| Alberta | 0.92 (0.91 to 0.94)† | — | — | — |
| Saskatchewan and Manitoba | 0.90 (0.88 to 0.91)† | — | — | — |
| Ontario | 0.74 (0.74 to 0.75)* | — | — | — |
| Atlantic | 0.46 (0.45 to 0.47)* | — | — | — |
| Donation year | 0.98 (0.98 to 0.98)* | — | — | — |
Notes: An interaction model was used for blood donors. Pediatric patients aged younger than 12 mo at transplant were excluded from regression analysis because of potential passive maternal antibody. No variable was significant in pediatric organ donor regression. Dashes indicate not applicable
* Significant at p < 0.001
§ Significant at p < 0.01
† Significant at p < 0.05
‡Organs were grouped as follows: kidney–pancreas with kidneys, small bowel and multivisceral with liver, and heart–lung with lung CMV = Cytomegalovirus; Ref. = Reference