Table 4.
EBV multivariate regression models for organ donors and recipients
| Variable | Odds ratio (95% CI) | |||
|---|---|---|---|---|
| Adult | Pediatric | |||
| Variable | Organ donor | Recipient | Donor | Recipient |
| Age | 1.04 (1.02 to 1.05)* | 1.05 (1.04 to 1.07)* | 1.08 (1.02 to 1.14)† | 1.16 (1.10 to 1.23)* |
| Sex | ||||
| Male | 1.00 (Ref.) | 1.00 (Ref.) | — | — |
| Female | 1.59 (1.10 to 2.31)* | 1.67 (1.17 to 2.43)† | — | — |
| Organ‡ | ||||
| Kidney | — | 1.00 (Ref.) | — | 1.00 (Ref.) |
| Liver | — | 0.88 (0.19 to 4.51) | — | 2.21 (1.12 to 4.50)§ |
| Heart | — | 2.41 (0.54 to 12.59) | — | 1.60 (0.80 to 3.26) |
| Lung | — | 0.09 (0.02 to 0.35)* | — | 1.06 (0.22 to 5.80) |
| Age × Lung | — | 1.06 (1.02 to 1.10)* | — | — |
| Age × Liver | — | 1.02 (0.98 to 1.06) | — | — |
| Age × Heart | — | 0.98 (0.94 to 1.00) | — | — |
| Period | ||||
| 1984–1998 | 1.00 (Ref.) | — | — | 1.00 (Ref.) |
| 1999–2013 | 1.49 (1.02 to 2.16)§ | — | — | 0.49 (0.26 to 0.88)§ |
Notes: Pediatric patients aged younger than 12 mo at transplant were excluded from the regression analysis because of potential passive maternal antibody. An interaction model was used for adult recipients. Pediatric donor regression revealed only age as a significant predictor. Dashes indicate not applicable
* Significant at p < 0.001
†Significant at p < 0.01
§ Significant at p < 0.05
‡Organs were grouped as follows: kidney–pancreas with kidneys, small bowel and multivisceral with liver, and heart–lung with lung
EBV = Epstein-Barr virus; OR = Odds ratio; CI = Confidence interval; Ref. = reference