Table 2.
Characteristics of major oncolytic viruses.
| Virus | Poxvirus
|
NewcastlediseaseVirus(NDV)
|
Reovirus 
|
Measles virus 
|
Herpes simplex virus 
|
AdenoViruses 
|
Parvovirus 
|
Poliovirus 
|
Vesicular Stomatitis Virus 
|
Seneca Valley Virus 
|
|---|---|---|---|---|---|---|---|---|---|---|
|
Genome
(Size) |
dsDNA (160–190 kb) |
SS (–) RNA (15 kb) | dsRNA (23 kb) |
SS (–) RNA (16 kb) | dsDNA (154 kb) | dsDNA (35 kb) |
ssDNA (5 kb) |
SS(+) RNA (7.5 kb) |
SS (–) RNA (11 kb) |
SS (+) RNA (7 kb) |
| Virion | Complex | Enveloped | Naked | Enveloped | Enveloped | Naked | Naked | Naked | Enveloped | Naked |
|
Replication
Site |
Cytoplasm | Nucleus | Cytoplasm | Nucleus | Nucleus | Nucleus | Nucleus | Cytoplasm | Cytoplasm | Cytoplasm |
| Receptor | Heparan, laminin, Chondroitin,integrin-1, CD98 |
Sialic acid | Sialic acid, JAM1 | SLAMF1 (CD150), CD46, Nectin 4 |
HVEM, Nectin 1, Nectin 2 |
CAR | Sialic acid residues, P antigens |
CD155 | LDLR | Anthrax toxin receptor 1 |