TABLE 3.
PK parameter estimates and bootstrap results of final model.
| Parameter | Final model | Bootstrap | ||||
|---|---|---|---|---|---|---|
| Estimate | RSE (%) | Shrinkage (%) | Median | 2.5, 97.5 percentiles | Shrinkage (%) | |
| OFV | -91.5 | — | — | -98.5 | -162.5, -45.2 | — |
| CL/F (L/h) | 14.8 | 8.5 | — | 14.5 | 11.0, 17.6 | — |
| Ka (h−1) | 2.0 | 18.2 | — | 2.1 | 1.4, 3.5 | — |
| Vc/F (L) | 6.0 | 25.5 | — | 6.6 | 3.1, 12.7 | — |
| Vp/F (L) | 269 | — | — | 269 | — | — |
| Q/F (L/h) | 15.4 | 27.7 | — | 15.2 | 6.8, 31.8 | — |
| θDOSE | 0.452 | 20.2 | — | 0.463 | 0.183, 0.934 | — |
| IIV CL/F (%) | 24.5 | 26.9 | 19.8 | 22.8 | 8.3, 33.5 | 22.2 |
| IIV Q/F (%) | 117.9 | 22.1 | 9.8 | 115.2 | 46.4, 161.2 | 10.6 |
| RV (%) | 50.3 | 7.3 | 8.2 | 49.2 | 41.4, 56.1 | 7.7 |
RES, percent relative standard error; θDOSE, typical population value of DOSE; IIV, interindividual variability; RV, residual variability.