Table 4.
Association of plasma Lp(a) levels with cardiovascular disease in a Mendelian randomization analysis (MR-PRESSO)
| N | RAW OR | 95% CI | Estimates P | outlier N | OR | Corrected 95% CI | Estimates P | |
|---|---|---|---|---|---|---|---|---|
| AA | 11 | 1.005 | 1.000–1.009 | 0.081 | NA | NA | NA | NA |
| CHD | 11 | 1.002 | 1.001–1.005 | 0.028 | NA | NA | NA | NA |
| ISL | 18 | 1.003 | 1.002–1.004 | 1.40E-06 | NA | NA | NA | NA |
| AF | 14 | 1.001 | 1.000–1.002 | 0.081 | NA | NA | NA | NA |
| HBP | 16 | 1.000 | 0.998–1.002 | 0.915 | NA | NA | NA | NA |
| HF | 12 | 0.999 | 0.997–1.002 | 0.564 | NA | NA | NA | NA |
| IS | 16 | 1.000 | 1.000–1.001 | 0.162 | NA | NA | NA | NA |
| LIS | 13 | 1.000 | 0.999–1.000 | 0.547 | NA | NA | NA | NA |
| ISS | 18 | 0.999 | 0.998–1.000 | 0.445 | NA | NA | NA | NA |
| PE | 16 | 0.999 | 0.998–1.000 | 0.228 | NA | NA | NA | NA |
OR odds ratio, CI confidence interval, AA aortic aneurysm, CHD coronary heart disease, ISL large artery atherosclerosis stroke, AF atrial fibrillation, HBP secondary hypertension HF heart failure, IS ischemic stroke, LIS lacunar stroke. ISS small vessel stroke, PE pulmonary embolism