Table 2.

Differential metabolites in the liver and their change trends among groups.

No.	Differential Metabolites	Mode	CYP vs. NC			MP+CYP vs. CYP
			VIP	FC	Trend	VIP	FC	Trend
1	Glycerophosphocholine	ESI+	1.66	0.80	↓ *	1.08	1.08	↑ *
2	LysoPA(18:1(9Z)/0:0)	ESI−	1.2	0.71	↓ *	1.69	1.27	↑ *
3	4-Trimethylammoniobutanoic acid	ESI+	1.11	0.72	↓ *	1.60	1.42	↑ *
4	Uridine	ESI+	2.07	0.82	↓ **	1.29	1.18	↑ *
5	Orotidine	ESI−	2.22	0.71	↓ ***	1.37	1.37	↑ *
6	S-Adenosylhomocysteine	ESI+	2.05	0.75	↓ *	1.06	1.30	↑ *
7	L-Methionine	ESI+	1.58	0.88	↓ *	1.70	1.17	↑ *
8	Uracil	ESI−	1.82	1.24	↓ *	1.12	1.02	↑ *
9	LysoPC(20:4(8Z,11Z,14Z,17Z))	ESI+	1.95	1.67	↑ *	1.71	0.64	↓ *
10	Deoxycytidine	ESI−	1.84	0.76	↑ *	1.20	0.76	↓ *
11	8,9-DiHETrE	ESI−	1.59	1.63	↑ *	1.16	0.70	↓ *
12	2-Amino-3,8-dimethyl-3H-imidazo [4,5-f]quinoxaline	ESI+	2.45	2.24	↑ ***	2.37	0.43	↓ ***
13	Ribose 1-phosphate	ESI−	1.47	1.33	↑ *	1.58	0.74	↓ *
14	PC(16:1(9Z)/16:1(9Z))	ESI+	1.19	2.23	↑ *	1.57	0.36	↓ *
15	Tetraacetylethylenediamine	ESI+	2.14	2.25	↑ ***	2.56	0.35	↓ ***
16	D-4′-Phosphopantothenate	ESI+	1.38	1.53	↑ *	1.67	0.62	↓ *
17	PC(22:5(4Z,7Z,10Z,13Z,16Z)/20:5(5Z,8Z,11Z,14Z,17Z))	ESI+	1.45	1.29	↑ *	1.75	0.75	↓ *
18	Saccharopine	ESI−	2.55	2.16	↑ ***	2.47	0.40	↓ ***
19	N-Acetylglutamic acid	ESI−	1.77	1.27	↑ *	2.33	0.68	↓ ***
20	Sedoheptulose	ESI+	1.27	1.79	↑ *	1.99	0.42	↓ **
21	Homocitrulline	ESI+	1.71	1.36	↑ *	1.77	0.66	↓ *

* p < 0.05, ** p < 0.01, *** p < 0.0001. The arrow (↑ and ↓) means the changing trend of biomarkers between groups.