Table 7.
Importance of pre-conception evaluation: when to defer or to contraindicate an SLE pregnancy.
| Evaluation | Deferred Conception | Contraindication for Pregnancy |
|---|---|---|
| Active disease in the last 6 months | ✓ | |
| Active lupus nephritis (still need for teratogenic regimen) | ✓ | |
| Severe pulmonary hypertension (>50 mmHg) | ✓ | |
| Severe restrictive lung disease (forced vital capacity < 1 L) | ✓ | |
| Advanced renal insufficiency (creatinine > 2.8 mg/dL) | ✓ | |
| Advanced heart failure | ✓ | |
| Stroke or major thrombotic event in the last 6 months | ✓ | |
| Previous PE or HELLP (Homolysis, Elevated Liver enzyme and Low Plates) syndrome despite correct treatment | ✓ | |
| Forbidden medication: changed first to approved medication and weight a few months to observe | ✓ | |
| Vaccination status: missing recommended vaccines | ✓ |
PE—Pre-eclampsia.