Table 2.

List of Salmonella strains under human clinical trials for cancer therapy.

Bacteria	Strain	Cancer Model	Result	Phase	References
S. Typhimurium	VNP20009	Metastatic melanoma and renal cell carcinoma	Focal tumor colonization was recorded without tumor regression	I	[33,167]
S. Typhimurium	VNP20009 expressing TAPET-CD (Cytosine deaminase)	Squamous cell carcinoma and adenocarcinoma	Intratumoral bacterial colonization in 2 out of 3 patients	I	[165]
S. Typhimurium	VNP20009	Solid tumors	Not provided	I	https://clinicaltrials.gov/ct2/show/NCT00006254 (accessed on 1 September 2022)
Salmonella typhi (Express VEGFR2)	Ty21a (VXM01)	Pancreatic cancer	VXM01 vaccination increased vaccine-specific T cell responses	I	[166]