Table 1.

Comparison of various cases reported in the literature. Several reported cases were studied to compare similarities and differences. The details of cases such as the age of onset, onset after vaccination, types of vaccine received, symptoms, diagnostic criteria used, and treatment are listed above; meanwhile, every symptom of the case above was summarized into a list for a clearer comparison.

	Newly Onset Adult-Onset Still’s Disease-like Syndrome after ChAdOx1 nCoV-19 Vaccination—A Case Series with Review of Literature [5]	Adult-Onset Still’s Disease after BNT162b2 mRNA COVID-19 Vaccine [6]	Adult-Onset Still’s Disease after mRNA COVID-19 Vaccine [7]	Present Patient
Age of onset (years) and sex	Case 1: 20 (female)	36 (female)	45 (female)	30 (female)
	Case 2: 47 (female)
	Case 3: 35 (female)
Onset after vaccination	Case 1: 10 days (1st dose)	10 days (1st dose)	5 days (2nd dose)	16 days (2nd dose)
	Case 2: 3 weeks
	Case 3: 3 months (1st dose)
Vaccine	ChAdOx1 nCoV-19	BNT162b2 mRNA COVID-19 vaccine (Pfizer)	Moderna (mRNA vaccine)	Moderna (mRNA vaccine)
Symptoms	Case 1: ■Fever (biquotidian) ■Sore throat ■Myalgia ■Arthralgia/arthritis ■Maculopapular rash □Significant weight loss □Loss of appetite □Lymphadenopathy □Macrophage activation syndrome □Diffuse edema □Splenomegaly □Headache □Pleurisy □General weakness □Chest pain	■Fever ■Sore throat □Myalgia ■Arthralgia/arthritis □Maculopapular rash □Significant weight loss □Loss of appetite ■Lymphadenopathy (paraaortic and aortocaval spaces) □Macrophage activation syndrome ■Diffuse edema (both hands and feet) ■Splenomegaly □Headache □Pleurisy □General weakness □Chest pain	■Fever ■Sore throat ■Myalgia ■Arthralgia/arthritis ■Maculopapular rash (upper back, dorsal aspect of the hands, and bilateral thighs) □Significant weight loss □Loss of appetite □Lymphadenopathy □Macrophage activation syndrome □Diffuse edema □Splenomegaly ■Headache ■Pleurisy □General weakness □Chest pain	■Fever ■Sore throat □Myalgia ■Arthralgia/arthritis ■Maculopapular rash (trunk and four limbs, and also on the right palm, sparing the face, without itch) □Significant weight loss □Loss of appetite □Lymphadenopathy □Macrophage activation syndrome □Diffuse edema □Splenomegaly □Headache □Pleurisy ■General weakness □Chest pain
	Case 2: ■Fever (quotidian) □Sore throat □Myalgia ■Arthralgia/arthritis □Maculopapular rash ■Significant weight loss ■Loss of appetite □Lymphadenopathy □Macrophage activation syndrome □Diffuse edema □Splenomegaly □Headache □Pleurisy □General weakness □Chest pain
	Case 3: ■Fever ■Sore throat □Myalgia ■Arthralgia/arthritis ■Maculopapular rash □Significant weight loss □Loss of appetite ■Lymphadenopathy ■Macrophage activation syndrome □Diffuse edema □Splenomegaly □Headache □Pleurisy □General weakness □Chest pain
Diagnostic Criteria of AOSD	Cases 1 and 2: Fautrel criteria Case 3: Yamaguchi criteria	Yamaguchi criteria	Yamaguchi criteria	Yamaguchi criteria
Treatment	Case 1: Naproxen	Steroid pulse therapy, intravenous tocilizumab	Prednisolone	Naproxen, methylprednisolone
	Case 2: Naproxen, tocilizumab, and low-dose methotrexate
	Case 3: Intravenous pulse methylprednisolone + intravenous immunoglobulin, intravenous tocilizumab
	Case Report: Adult Onset Still’s Disease after vaccination against COVID-19 [8]	Adult-Onset Still’s Disease After the ChAdOx1 nCoV-19 Vaccine [9]	Adult-onset Still’s disease following COVID-19 vaccination [10]
Age of onset (years) and sex	47 (female)	29 (male)	36 (male)
Onset after vaccination	7 days (1st dose)	2 days (1st dose)	1 day (1st dose)
Vaccine	ChAdOx1 nCoV-19	ChAdOx1 nCoV-19	ChAdOx1 nCoV-19
Symptoms	■Fever ■Sore throat □Myalgia ■Arthralgia/arthritis ■Maculopapular rash (bilaterally involving thighs, legs, and hands) □Significant weight loss □Loss of appetite □Lymphadenopathy □Macrophage activation syndrome □Diffuse edema ■Splenomegaly □(hepatosplenomegaly) □Headache □Pleurisy □General weakness □Chest pain	■Fever ■Sore throat ■Myalgia ■Arthralgia/arthritis ■Maculopapular rash (face, trunk and extremities) □Significant weight loss □Loss of appetite □Lymphadenopathy □Macrophage activation syndrome □Diffuse edema □Splenomegaly ■Headache □Pleurisy □General weakness □Chest pain	■Fever ■Sore throat □Myalgia □Arthralgia/arthritis ■Maculopapular rash □Significant weight loss □Loss of appetite ■Lymphadenopathy □Macrophage activation syndrome □Diffuse edema ■Splenomegaly □Headache □Pleurisy □General weakness ■Chest pain
Diagnostic Criteria of AOSD	Yamaguchi criteria	Yamaguchi criteria	Yamaguchi criteria
Treatment	Prednisolone, methotrexate	Methylprednisolone	Methylprednisolone