Table 4.
Comparison in peripheral blood immune phenotypes between PAO (n=22), PsA (n=33), and HCs (n=30)
| HC | PsA | PAO | p value | |||
|---|---|---|---|---|---|---|
| HC vs PsA | HC vs PAO | PsA vs PAO | ||||
| CD4+ T cells | ||||||
| Naive | 55.7 (43.5, 61.3) | 49.2 (32.3, 60.0) | 51.6 (45.0, 63.2) | 0.8780 | 1.0000 | 0.9810 |
| Central memory | 34.4 (25.3, 41.7) | 32.8 (24.6, 44.6) | 31.5 (23.0, 37.8) | 1.0000 | 1.0000 | 1.0000 |
| Effector memory | 11.1 (6.8, 15.6) | 10.1 (7.4, 17.8) | 10.0 (6.5, 14.9) | 1.0000 | 1.0000 | 1.0000 |
| TEMRA | 2.4 (1.5, 4.0) | 3.2 (2.1, 4.7) | 2.5 (1.5, 4.6) | 0.2980 | 1.0000 | 0.6955 |
| Th1 | 17.7 (13.1, 26.0) | 20.5 (17.0, 24.4) | 17.8 (12.3, 19.8) | 0.6549 | 1.0000 | 0.1041 |
| Th17 | 9.8 (7.6, 12.8) | 10.9 (9.1, 14.7) | 12.1 (9.3, 16.6) | 0.8311 | 0.1874 | 1.0000 |
| Treg | 4.6 (3.8, 5.6) | 4.7 (3.6, 5.7) | 4.3 (3.3, 5.7) | 1.0000 | 1.0000 | 1.0000 |
| Tfh | 0.8 (0.7, 1.4) | 0.7 (0.3, 1.4) | 0.8 (0.7, 1.1) | 0.6043 | 1.0000 | 0.8582 |
| CD8+ T cells | ||||||
| Naive | 40.7 (24.9, 54.9) | 44.4 (34.5, 56.2) | 34.4 (29.2, 49.7) | 1.0000 | 1.0000 | 0.3747 |
| Central memory | 8.2 (4.9, 28.5) | 17.1 (9.7, 26.9) | 19.9 (13.4, 29.3) | 0.2300 | 0.1120 | 1.0000 |
| Effector memory | 12.9 (9.0, 27.5) | 9.8 (5.3, 19.8) | 19.8 (10.6, 24.9) | 0.1757 | 1.0000 | 0.0649 |
| TEMRA | 21.7 (11.6, 29.9) | 18.8 (12.0, 31.9) | 17.8 (12.4, 28.6) | 1.0000 | 1.0000 | 1.0000 |
| Activated T cells | ||||||
| CD4+ | 4.8 (3.1, 7.1) | 4.3 (2.3, 7.1) | 3.4 (2.3, 6.0) | 1.0000 | 0.6483 | 1.0000 |
| Th1 | 1.0 (0.6, 1.7) | 1.2 (0.8, 1.6) | 0.4 (0.2, 0.5) | 0.7808 | *<0.0001 | *<0.0001 |
| Th17 | 0.6 (0.4, 0.7) | 1.1 (0.5, 1.5) | 1.1 (0.5, 1.8) | *0.0032 | *0.0164 | 1.0000 |
| Treg | 1.1 (1.0, 1.5) | 0.9 (0.6, 1.4) | 1.4 (0.7, 1.8) | 0.3430 | 1.0000 | 0.2660 |
| Tfh | 0.3 (0.2, 0.5) | 0.2 (0.1, 0.5) | 0.3 (0.2, 0.4) | 1.0000 | 1.0000 | 0.5850 |
| CD8+ | 8.9 (5.9, 13.4) | 6.8 (4.8, 13.1) | 6.5 (3.8, 11.2) | 0.6867 | 0.3812 | 1.0000 |
| B cells | ||||||
| Naive | 61.8 (51.0, 69.4) | 65.4 (58.4, 73.4) | 62.0 (55.4, 68.8) | 0.2550 | 1.0000 | 0.8862 |
| IgM memory | 20.8 (10.9, 25.6) | 18.1 (13.8, 22.9) | 16.4 (10.3, 21.1) | 0.8355 | 0.231 | 1.0000 |
| Class-switched | 11.7 (8.9, 19.3) | 10.6 (7.5, 15.7) | 11.9 (8.2, 17.0) | 0.8051 | 1.0000 | 1.0000 |
| Double negative | 5.3 (4.2, 6.6) | 6.1 (4.4, 10.1) | 5.1 (3.8, 7.9) | 0.3217 | 1.0000 | 0.7185 |
| Plasmocytes | 2.0 (1.3, 2.9) | 1.5 (0.4, 2.4) | 2.5 (0.6, 4.8) | 0.1329 | 1.0000 | 0.3199 |
| Monocytes | ||||||
| Classical | 90.2 (82.9, 93.1) | 92.3 (89.2, 94.6) | 91.3 (86.1, 94.1) | 0.0967 | 0.7704 | 1.0000 |
| Non-classical | 9.5 (5.0, 15.3) | 7.4 (5.3, 10.7) | 6.0 (4.1, 11.6) | 0.6651 | 0.3034 | 1.0000 |
| Dendritic cells | ||||||
| Myeloid | 82.3 (69.6, 86.6) | 74.6 (61.2, 82.5) | 75.5 (67.7, 85.3) | 0.3641 | 1.0000 | 1.0000 |
| Plasmacytoid | 5.5 (3.8, 7.9) | 6.9 (4.5, 11.5) | 6.9 (4.9, 10.3) | 0.2533 | 0.3666 | 1.0000 |
| NK cells | ||||||
| CD16+ | 94.7 (89.5, 97.0) | 92.7 (88.9, 94.6) | 91.8 (84.5, 95.0) | 0.4355 | 0.1611 | 1.0000 |
| CD16- | 4.9 (2.9, 9.1) | 6.9 (4.6, 10.0) | 7.9 (3.8, 12.9) | 0.2301 | 0.3357 | 1.0000 |
Data are shown by median (quartile). p values were determined by the Dunn test
PAO pustulotic arthro-osteitis, PsA psoriatic arthritis, TEMRA terminally differentiated effector memory cells, Tfh follicular helper T cells
*p<0.05: HC (n=30) vs PsA (n=33) vs PAO (n=22)