Table 2.
Results were obtained for the generalized linear models used with the (i) clinical variables, (ii) metabolites, and (iii) clinical variables and metabolites. * means statistically significant
| Estimate | Std. error | z value | Pr( >|z|) | ||
|---|---|---|---|---|---|
| Clinical variables | Intercept | − 0.43249 | 0.18301 | − 2.363 | 0.0181* |
| Sex | − 0.08264 | 0.16283 | − 0.508 | 0.6118 | |
| Age baseline | 0.09660 | 0.16102 | 0.600 | 0.5486 | |
| HDL Imputed | 0.10651 | 0.16663 | 0.639 | 0.5227 | |
| TG Imputed | − 0.27225 | 0.17275 | − 1.576 | 0.1150 | |
| BMI baseline | 0.44999 | 131.228 | 0.343 | 0.7317 | |
| Intensity statin therapy | − 0.11911 | 0.15505 | − 0.768 | 0.4424 | |
| Metabolites | Intercept | − 0.459189 | 0.704513 | − 0.652 | 0.5145 |
| Sphingosine (d18:2) | − 0.107924 | 0.260230 | − 0.415 | 0.6783 | |
| Docosenamide | 0.004636 | 0.004572 | 1.014 | 0.3106 | |
| Oxo-tricosanoic acid | − 0.002283 | 0.003195 | − 0.714 | 0.4750 | |
| Tetracosahexaenoic acid | − 0.003083 | 0.003112 | − 0.991 | 0.3219 | |
| Ketodeoxycholic acid | − 0.293914 | 0.290994 | − 1.010 | 0.3125 | |
| Stearoylcarnitine | − 0.436030 | 0.230849 | − 1.889 | 0.0589 | |
| Diglyceride (33:4) | 0.194136 | 0.198864 | 0.976 | 0.3290 | |
| Creatine | − 0.001211 | 0.003222 | − 0.376 | 0.7071 | |
| Tridecanoic acid | − 0.001950 | 0.003332 | − 0.585 | 0.5584 | |
| Monoacylglycerol (22:6) | 0.003391 | 0.003096 | 1.095 | 0.2733 | |
| Dihydroxycholesterol | − 0.327887 | 0.177616 | − 1.846 | 0.0649 | |
| Biliverdin | − 0.362871 | 0.179566 | − 2.021 | 0.0433* | |
| Clinical variables and metabolites | Intercept | − 0.330027 | 0.726670 | − 0.454 | 0.6497 |
| Sphingosine (d18:2) | − 0.042235 | 0.271197 | − 0.156 | 0.8762 | |
| Docosenamide | 0.004359 | 0.004724 | 0.923 | 0.3561 | |
| Oxo-tricosanoic acid | − 0.002246 | 0.003257 | − 0.689 | 0.4905 | |
| Tetracosahexaenoic acid | − 0.004089 | 0.003290 | − 1.243 | 0.2139 | |
| Ketodeoxycholic acid | − 0.321368 | 0.302763 | − 1.061 | 0.2885 | |
| Stearoylcarnitine | − 0.461926 | 0.236503 | − 1.953 | 0.0508 | |
| Diglyceride (33:4) | 0.184457 | 0.208359 | 0.885 | 0.3760 | |
| Creatine | − 0.001613 | 0.003291 | − 0.490 | 0.6241 | |
| Tridecanoic acid | − 0.001681 | 0.003458 | − 0.486 | 0.6268 | |
| Monoacylglycerol (22:6) | 0.003439 | 0.003158 | 1.089 | 0.2761 | |
| Dihydroxycholesterol | − 0.307896 | 0.182783 | − 1.684 | 0.0921 | |
| Biliverdin | − 0.348474 | 0.181466 | − 1.920 | 0.0548 | |
| Sex | − 0.091159 | 0.178688 | − 0.510 | 0.6099 | |
| Age baseline | 0.142588 | 0.177915 | 0.801 | 0.4229 | |
| HDL Imputed | 0.053527 | 0.188053 | 0.285 | 0.7759 | |
| TG Imputed | − 0.223763 | 0.185640 | − 1.205 | 0.2281 | |
| BMI baseline | 0.402986 | 1.322.298 | 0.305 | 0.7605 | |
| Intensity Statin Therapy | − 0.214802 | 0.174998 | − 1.227 | 0.2197 |