Figure 3.

(A) In vitro hepatocyte clearance of chemicals in suspension culture (squares), sandwich culture (circles), OrganoPlate^® 2-lane 96 (triangles), and httk (diamonds). Plotted are in vitro hepatocyte clearances (mean) of each chemical listed (the number in brackets indicates the LogP of each compound). Experiments were conducted using induced pluripotent stem cell-derived hepatocytes (iHep). Each chemical was tested at 1 µM in a mixture setting. Clearance values reported for each chemical in httk R package version 1.10.1 were tested using primary human hepatocyte suspensions at 10 µM in a single chemical setting. (B) 3D plot showing hepatocyte clearance of each chemical across the three in vitro models used in this study. Axes represent in vitro clearance values for each compound in a 1 µM mixture. All data points for each model can be found in Table S3.