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. 2022 Oct 11;12(10):961. doi: 10.3390/metabo12100961

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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One-carbon enzymes are modified post-translationally. Enzymes involved in the one carbon metabolism pathway undergo a variety of post-translational modifications (PTMs), including phosphorylation, acetylation, methylation, and ubiquitylation. Several modifications (MTHFR phosphorylation and MTHFD1 methylation) affect protein activity and efficiency, thereby altering one carbon metabolic flux. Since identifying many other PTMs with proteomic screens, the biological effects of several other PTMs remain undefined. Note that the illustrated modifications only represent a selection of identified PTMs. Y, tyrosine; K, lysine; S, serine; R, arginine; T, threonine. P, phosphorylation; Ac, acetylation; Me, methylation; U, ubiquitylation. Figure made with BioRender.