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. 2022 Oct 11;12(10):961. doi: 10.3390/metabo12100961

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dietary vitamin B6 and folate are essential for human health. Diets high in vitamin B6- and B9-rich foods (left) correlate with decreased risks of several cancers, but may mask the symptoms of a vitamin B12 deficiency, increase risk of ovarian and AML cancers, aggravate pellagra symptoms, and lead to numbness, nerve damage, and muscle pain. Diets low in vitamin B6- and B9-rich foods (right) can lead to dermatitis, glossitis, cheilitis, nausea, confusion, dream loss, as well as an increased risk of several cancers and a decreased risk of AML. Figure made with BioRender.