Table 1.

Pharmacokinetics of ibuprofen and mefenamic acid [10,15].

NSAIDs	Absorption	Distribution	Metabolism	Excretion	Half-Life
Mefenamic acid	BA: easily absorbed Tmax: 2–4 h	Vd: 1.06 L/kg PB: >90%	Hepatic; mainly via CYP2C9	Renal: 52% Fecal: 20%	2–4 h
Ibuprofen	BA: 80% Tmax: 1–2 h	Vd: 0.12-2 L/kg PB: 90–99%	Hepatic; rapidly metabolized via CYP2C9	Renal: 45–79%	1.8–2.44 h

BA, bioavailability; PB, protein binding; Tmax, time to maximum plasma concentration; Vd, volume of distribution.