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. 2022 Oct 14;14(20):4284. doi: 10.3390/nu14204284

Figure 6.

Figure 6

Long-term MO treatment prevents synaptic proteins and dendritic spines losses and neurodegeneration in APP/PS1 mice. (A) The expression level of PSD95 and Synapsin1 from hippocampal lysates of WT control and APP/PS1 mice with or without MO treatment was examined by Western blotting, (n = 3). (B,C) The statistical analysis of Western blot bands from panel A. β-actin serves as the loading control. (D–F) Golgi staining results. (D) The representative micrographs of the Golgi staining experiment (scale bare = 5 μm, n = 3 per group, 3–4 dendrites per mouse). (E) Total spines number per 10 μm area. (F) The mushroom-type spines per 10 μm area. (G–I) Nissl staining results (scale bars = 100, 200, 400, and 500 μm, n = 3). (G) The representative micrographs of the Nissl staining experiment. (H) The number of neurons per area. (I) The thickness (mm) of the cortex. The data are presented as Mean ± SEM. * p < 0.05; ** p < 0.01; and *** p < 0.001 vs. WT or vs. APP/PS1 mice groups.