Table 2.
The literature models describing neonatal gentamicin pharmacokinetics selected for evaluation and collected data covariates. Current study data covariates are also described. Values are given as counts (for patients, samples), median (range) or mean (standard deviation). PNA postnatal age; GA gestational age; PMA postmenstrual age; WT current weight; HT height; CR serum creatinine; CRCL creatinine clearance; NG not given.
| Model | Pts | Samples | PNA (d) | GA (wk) | WT (kg) | CR (mg/dL) | Model Covariates |
|---|---|---|---|---|---|---|---|
| Bijleveld [13] | 65 | 136 | 1 (0–31) |
32 (25–42) |
1.84 (0.43–4.67) | 0.63 (0.29–1.3) | WT, PMA |
| De Cock [14] | 717 | 1705 | 2 (1–5475) |
(23–43) |
2.6 (0.44–80) |
0.82 (0.14–1.18) | WT |
| Fuchs [10] | 1518 | 3039 | 1 (0–94) |
34 (24–42) |
2.2 (0.44–5.5) |
NG | WT, GA, PNA, dopamine coadmin |
| Garcia [15] | 200 | 417 | 5.49 (5.41) |
32.19 (2.97) |
1.68 (0.63) |
NG | WT, PNA, CRCL |
| Germovsek [11] | 205 | 1325 | 5.1 (1–66) |
34 (23.3–42.1) |
2.12 (0.53–5.05) |
NG | WT, GA, PNA, CR |
| Wang [12] | 2357 | 6359 | 1 (1–6924) |
37 (21–42) |
3.43 (1.1–5.83) |
0.66 (0.14–3.8) |
WT, HT, CR, PNA, PMA |
| Current Study Data | 475 | 842 | 1.46 (0.36–81.9) |
36.7 (23.7–43) |
2.76 (0.37–5.44) |
0.64 (0.15–2.79) |
- |