Figure 1.

Longitudinal profile of total serum bile acid (A), 7α-C4 (B), total serum bile acid change from baseline (%) (C), and ItchRO score levels (D) over 72 weeks, i.e., baseline, 4, 8, 13, 48, 60, and 72 weeks of maralixibat treatment in pruritus responders vs. non-responders, data were represented as mean ± SE; composition of serum bile acid following 72 weeks of maralixibat treatment in pruritus responders vs. non-responders (E). * p ≤ 0.05, ** p ≤ 0.01. 7α -C4, 7 alpha -hydroxy-4-cholesten-3-one.