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. 2022 Oct 6;12(10):952. doi: 10.3390/metabo12100952

Figure 2.

Figure 2

Correlation between change from baseline of conjugated serum bile acid species GCA, Pearson’s r 0.549 (p-value < 0.001) (A) and TCA, Pearson’s r 0.605 (p-value < 0.001) (B), and reduction in the ItchRO(Obs) score following 72 weeks of maralixibat treatment, correlation coefficients were calculated using full patient cohort. Background highlighted in green indicates reduction in both ItchRO(Obs) score and measured sBA % change from baseline. GCA, glycine-conjugated cholic acid; ItchRO(Obs), itch reported outcome score from observer; sBA, serum bile acid; and TCA, taurine-conjugated cholic acid. Two subjects are excluded due to baseline ItchRO(OBs) scores < 1.0. Profile of GCA (C) and TCA (D) following 72 weeks of maralixibat treatment. * indicates significant p-value, i.e., at 0.05 level, between pruritus responders vs non-responders at a given time point.