Figure 3.

Evaluation of total sBA as a biomarker (predictor) in building the LMM model. Coefficients of fixed factors/effects, i.e., total sBA concentration during the study period, weeks of patients on MRX in study, initial age and gender of patients, and sBA pre-dose baseline from LMM model, whiskers span the 95% CI, *** p-value < 0.001, color of a dot indicate the factor/covariate has negative (red) or positive (blue) effects on ItchRO score (A); QQ-plot of residuals for normality check (B); residual plot against the fitted values for homoscedasticity (C); and histogram of normalized residuals (D).