Table III.
Distribution of health-related quality of life with EQ-5D-3L dimension in relation to atopic dermatitis (AD) at the 24-year clinical examination (n = 2,270a) and persistent AD
| Dimensions | No AD | ADb | p-value | No ADc | Persistent ADd | p-value |
|---|---|---|---|---|---|---|
| (n = 1,839) | (n = 420) | (n = 1,375) | (n = 180) | |||
| n (%) | n (%) | n (%) | n (%) | |||
| Mobility | ||||||
| No problems | 1,796 (97.7) | 416 (99.1) | 1,352 (98.3) | 178 (98.9) | ||
| Some problems | 42 (2.3) | 4 (1.0) | 0.23 | 22 (1.6) | 2 (1.1) | 1.0 |
| Extreme problems | 1 (0.05) | 0 (0.0) | 1 (0.07 ) | 0 (0.0) | ||
| Self-care | ||||||
| No problems | 1,827 (99.4) | 418 (99.8) | 1,367 (99.4) | 180 (100.0) | ||
| Some problems | 9 (0.5) | 1 (0.2) | 0.84 | 6 (0.4) | 0 (0.0) | 1.0 |
| Extreme problems | 3 (0.2) | 0 (0.0) | 2 (0.2) | 0 (0.0) | ||
| Usual activities | ||||||
| No problems | 1,713 (93.2) | 389 (92.6) | 1,292 (94.0) | 169 (93.9) | ||
| Some problems | 119 (6.5) | 28 (6.7) | 0.57 | 82 (6.0) | 11 (6.1) | 0.88 |
| Extreme problems | 7 (0.4) | 3 (0.7) | 1 (0.07) | 0 (0.0) | ||
| Pain/discomfort | ||||||
| No problems | 1,371 (74.6) | 263 (62.6) | 1,057 (76.9) | 114 (63.3) | ||
| Some problems | 456 (24.8) | 156 (37.1) | < 0.001 | 312 (22.7) | 65 (36.1) | <0.001 |
| Extreme problems | 11 (0.6) | 1 (0.2) | 6 (0.4) | 1 (0.6) | ||
| Anxiety/depression | ||||||
| No problems | 1,147 (62.4) | 240 (57.1) | 877 (63.8) | 98 (54.4) | ||
| Some problems | 650 (35.4) | 167 (39.8) | 0.11 | 472 (34.3) | 75 (41.7) | 0.02 |
| Extreme problems | 42 (2.3) | 13 (3.1) | 26 (1.9) | 7 (3.9) | ||
| EQ VAS mean | 79.4 | 77.6 | 0.01 | 79.8 | 76.0 | < 0.001 |
| EQ VAS median (95% CI) | 80 (79.6–80.4) | 80 (79.2–80.8) | 1.00 | 80 (79.2–80.8) | 80 (77.8–82.2) | 1.00 |
| EQ VAS 25th percentile (95% CI) | 73 (72.2–73.8) | 70 (68.4–71.6) | < 0.001 | 75 (74.0–76.0) | 70 (67.3–72.7) | < 0.001 |
| EQ VAS 75th percentile (95% CI) | 90 (89.5–90.5) | 87 (86.0–88.0) | < 0.001 | 90 (89.5–90.4) | 85 (83.7–86.3) | < 0.001 |
EQ-5D-3L: descriptive system for health-related quality of life, with 5 dimension and 3 severity levels; EQ VAS: visual analogue scale (VAS) of current health-related quality of life, the best imaginable health to the worst imaginable health (0–100) (analysed with Fischer’s exact test). Bold numbers are statistically significant.
95% CI: 95% confidence interval.
Missing 11.
Atopic dermatitis at 24 years defined as: itchy rash and dry skin in the preceding 12 months, history of flexural AD, asthma and/or rhinitis, onset before 2 years of age.
Participants without atopic dermatitis at 12-, 16- or 24-years.
Atopic dermatitis at 12 and/or 16 and 24 years of age, defined as: dry skin in combination with itchy rash of typical localization