Table 1:
Patient and Treatment Characteristics
| Characteristic | IMRT (N=1282) | PBT (N=568) | Total (N=1850) | P Value | |
|---|---|---|---|---|---|
|
| |||||
| Age | Median (Range) | 68 (43–89) | 67 (41–88) | 67 (41–89) | 0.002 |
| Treatment Year | 1998–2018 | 2008–2018 | 1998–2018 | <0.001 | |
| BMI | Median (Range) | 28.3 (16.2–56.6) | 27.3 (18.3–65.0) | 28.0 (16.2–65.0) | 0.11 |
| NCCN Risk Group | Low Risk | 377 (29.4%) | 154 (27.1%) | 531 (28.7%) | 0.31 |
| Intermediate Risk | 905 (70.6%) | 414 (72.9%) | 1319 (71.3%) | ||
| Tumor Stage | T1c | 825 (64.4%) | 389 (68.5%) | 1214 (65.6%) | 0.21 |
| T2 | 444 (34.6%) | 178 (31.3%) | 622 (33.6%) | ||
| Unknown | 13 (1.0%) | 1 (0.2%) | 14 (0.8%) | ||
| Baseline PSA | Median | 6.7 | 5.6 | 6.3 | <0.001 |
| <10 ng/mL | 941 (74.4%) | 490 (87.0%) | 1431 (78.3%) | ||
| 10–20 ng/mL | 324 (25.6%) | 73 (13.0%) | 397 (21.7%) | ||
| Gleason Score | 6 or less | 552 (43.1%) | 193 (34.0%) | 745 (40.3%) | <0.001 |
| 7 | 730 (56.9%) | 375 (66.0%) | 1105 (59.7%) | ||
| Anti-Coagulant | Yes | 394 (30.7%) | 66 (11.6%) | 460 (24.9%) | <0.001 |
| No | 814 (63.5%) | 366 (64.4%) | 1180 (63.8%) | ||
| Unknown | 74 (5.8%) | 136 (23.9%) | 210 (11.4%) | ||
| Baseline IPSS | mean (SD) | 10.9 (6.8) | 7.7 (5.4) | 9.2 (6.3) | <0.001 |
| Race | Caucasian | 888 (69.3%) | 488 (85.9%) | 1376 (74.4%) | <0.001 |
| African American | 366 (28.5%) | 47 (8.3%) | 413 (22.3%) | ||
| Other/Unknown | 28 (2.2%) | 33 (5.8%) | 61 (3.3%) | ||
| Smoking Status | Current Smoker | 105 (8.2%) | 22 (3.9%) | 127 (6.9%) | <0.001 |
| Former Smoker | 450 (35.1%) | 89 (15.7%) | 539 (29.1%) | ||
| Never Smoker | 399 (31.1%) | 85 (15.0%) | 484 (26.2%) | ||
| Unknown | 328 (25.6%) | 372 (65.5%) | 700 (37.8%) | ||
| Alcohol Use | Current Use | 71 (5.5%) | 17 (3.0%) | 88 (4.8%) | <0.001 |
| Former Use | 371 (28.9%) | 125 (22.0%) | 496 (26.8%) | ||
| No Use | 429 (33.5%) | 48 (8.5%) | 477 (25.8%) | ||
| Unknown | 411 (32.1%) | 378 (66.5%) | 789 (42.6%) | ||
| Cardiac Disease | Yes | 115 (9.0%) | 48 (8.5%) | 163 (8.8%) | 0.29 |
| No | 306 (23.9%) | 155 (27.3%) | 461 (24.9%) | ||
| Unknown | 861 (67.2%) | 365 (64.3%) | 1226 (66.3%) | ||
| Diabetes | Yes | 194 (15.1%) | 32 (5.6%) | 226 (12.2%) | <0.001 |
| No | 780 (60.8%) | 308 (54.2%) | 1088 (58.8%) | ||
| Unknown | 308 (24.0%) | 228 (40.1%) | 536 (29.0%) | ||
| ADT Use | Yes | 497 (38.8%) | 47 (8.3%) | 544 (29.4%) | <0.001 |
| No | 537 (41.9%) | 343 (60.4%) | 880 (47.6%) | ||
| Unknown | 248 (19.3%) | 178 (31.3%) | 426 (23.0%) | ||
| RT Fractionation | 70 Gy in 28 fx | 905 (70.6%) | 410 (72.2%) | 1315 (71.1%) | <0.001 |
| 70.2 Gy in 26 fx | 280 (21.8%) | 49 (8.6%) | 329 (17.8%) | ||
| 60 Gy in 20 fx | 97 (7.6%) | 35 (6.1%) | 132 (7.1%) | ||
| 72.5 Gy in 29 fx | 0 (0.0%) | 74 (13.0%) | 74 (4%) | ||
| Rectal Spacer | Yes | 0 (0.0%) | 21 (3.7%) | 21 (1.1%) | 0.051 |
| No | 100 (100.0%) | 547 (96.3%) | 1829 (98.9%) | ||
| Rectal Balloon | Yes | 0 (0.0%) | 82 (14.4%) | 82 (4.4%) | <0.001 |
| No | 100 (100.0%) | 486 (85.6%) | 1768 (95.6%) | ||
| Institutions | 1 | 0 (0.0%) | 184 (32.4%) | 184 (9.9%) | N/A |
| 2 | 0 (0.0%) | 215 (37.9%) | 215 (11.6%) | ||
| 3 | 0 (0.0%) | 81 (14.3%) | 81 (4.4%) | ||
| 4 | 248 (19.3%) | 88 (15.5%) | 336 (18.2%) | ||
| 5 | 610 (47.6%) | 0 (0.0%) | 610 (33.0%) | ||
| 6 | 285 (22.2%) | 0 (0.0%) | 285 (15.4%) | ||
| 7 | 139 (10.8%) | 0 (0.0%) | 139 (7.5%) | ||