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. 2022 Oct 21;14(20):4415. doi: 10.3390/nu14204415

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scatterplots of the 48 h change in the PaO2/FiO2 ratio and the change in the plasma syndecan-1 during the same time-period. The figure illustrates the change of the PaO2/FiO2 ratio, a marker of oxygenation and lung injury which corresponds to the change in the plasma biomarker syndecan-1 among the two groups, Placebo and HDIVC. The linear fitted line corresponds to the regression line for each group: Placebo and HDIVC, respectively. The subjects of the placebo group are represented with red x symbols, and the subjects of the HDIVC group are represented with blue triangles. Abbreviations: FiO2, fraction of inspired oxygen; HDIVC, high-dose intravenous vitamin C; PaO2, arterial oxygen pressure.