. 2022 Sep 29;12(10):920. doi: 10.3390/metabo12100920

Table 2.

Estimates of HGA * equivalents generated pre- and peri-nitisinone to calculate burden of accumulating HGA over time.

uHGA₂₄	36,361 umol or 6.1 g per day
All HGA equivalents pre-NIT in TBW and 24-h urine	42,268 umol or 7.1 g per day or 46.4% total daily PHE/TYR flux
All HGA equivalents during NIT	91,145 umol or 15.32 g per day
Additional HGA equivalents during NIT	8.21 g or 53.6% total daily PHE/TYR flux per day
Additional HGA equivalents during NIT per year (365 days)	2997 g or 3.0 kg per year
Additional HGA equivalents during NIT per 10 years	30 kg per 10 years

* HGA MW 168 g/mol used in calculation; PHE/TYR/HPPA/HPLA and HGA all considered molar equivalents in these calculations.