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. 2022 Oct 4;10(10):586. doi: 10.3390/toxics10100586

Table 2.

The study parameters and effects of accumulation of MPs on the liver.

Research Object Particle Size Material Number of Particles Concentration Mode of Exposure Exposure Time Summary Reference
Zebrafish 2.34 ± 0.07 μm PLABio MPs - 2.5, 5 mg/L In water 30 days PLABio MPs at concentrations of 2.5 and 5 mg/L could accumulate in the liver. [45,55]
Zebrafish 5 μm PS 2.9 × 102, 2.9 × 103, 2.9 × 104 particles/mL 20, 200, 2000 μg/L In water 7 days PS-MPs accumulated in the fish liver after 7 days of exposure. [27]
Male crab C. japonica 5 μm PS 1.0 × 103 particles/mL 0.68 × 10−4 mg/mL In water 7 days PS-MPs accumulated the most in crab hepatopancreas. [56]
Male mice 5, 20 μm PS 1.46 × 106 items (5 μm), 2.27× 104 items
(20 μm)
0.1 mg/day Oral gavage 28 days After 4 weeks of exposure, the maximum tissue concentration of PS-MPs in the liver was 0.303 ± 0.029 mg/g. [29]
Marine medaka 10 μm PS - 2, 20, 200 μg/L In water 60 days PS-MPs were accumulated in the liver of marine medaka at all exposure doses. [53,57]
Marine medaka 10 μm PS 1.82 × 1010 particles/m3 10 mg/L In water 30–60 days It was observed that over 30 spherical PS with a diameter ≤3 μm accumulated in the exposed group. [48]
Male Swiss mice 35.46 ± 18.17 μm PE - 60 mg/L Oral gavage 7 days PE-MPs could accumulate in the mouse liver. [54,58]
Red tilapia 70~90 μm PS 3.51 × 104 particles/mL 100 μg/L In water 14 days PS-MPs could accumulate in the tilapia liver, and it showed a generally increasing tendency with time. [44]

PLABio MPs: polylactic acid bio microplastics; -: unknown.