Table 2.
Significant serum metabolites discriminating individuals with overweight/obesity from lean individuals at baseline.
| Metabolites | Monoisotopic Neutral Mass [Da] |
RT [min] |
OW/OB vs. NW | ||
|---|---|---|---|---|---|
| Change * [%] |
VIP | Absolute p(corr) |
|||
| Bilirubin | 584.2621 | 8.0 | −30 | 1.82 | 0.52 |
| 584.2634 | 8.0 | −34 | 2.12 | 0.41 | |
| Leucine (S) | 131.0947 | 0.3 | 33 | 1.45 | 0.65 |
| Valine | 117.0788 | 0.2 | −28 | 1.88 | 0.51 |
| Piperidine | 85.0892 | 0.3 | 41 | 1.80 | 0.73 |
| Linoleamide (S) | 279.2558 | 5.5 | 66 | 1.65 | 0.53 |
| Dodecanamide (S) | 199.1938 | 5.3 | 32 | 1.51 | 0.57 |
| Palmitoleamide (S) | 253.2406 | 6.3 | 79 | 2.17 | 0.68 |
| HETE | 320.2348 | 5.8 | 43 | 1.78 | 0.49 |
| LPC 18:1 | 507.3684 | 6.0 | 21 | 1.29 | 0.43 |
| LPA 16:0 | 410.2430 | 5.7 | 20 | 1.39 | 0.51 |
| LPI 16:0 | 572.2964 | 5.8 | 51 | 1.48 | 0.53 |
| LPI 18:0 | 600.3278 | 6.8 | 31 | 1.15 | 0.43 |
| LPI 18:1 | 598.3119 | 6.1 | 37 | 1.82 | 0.61 |
| PC 36:5 | 779.5468 | 9.4 | −45 | 1.98 | 0.64 |
| PC 38:6 | 805.5624 | 9.8 | −26 | 1.60 | 0.47 |
| PC O–36:5 or P–36:4 | 765.5682 | 10.4 | −30 | 1.83 | 0.52 |
| PC 38:5 | 807.5777 | 10.1 | −44 | 2.67 | 0.67 |
* Positive/negative value of percent of change means higher/lower intensity of metabolite in people with overweight/obesity in comparison to lean individuals. The p(corr) and VIP values were calculated based on respective PLS-DA models. Variables with VIP > 1.0 and absolute p(corr) > 0.4 were considered significant. RT: retention time, VIP: variable importance into the projection, p(corr): predictive loading value, S: the identity of these metabolites was confirmed by analysis of the standard, HETE: hydroxyeicosatetraenoic acid, LPC: lysophosphatidylcholine, LPA: lysophosphatidic acid, LPI: lysophosphatidylinositol, PC: phosphatidylcholine.