Table 4.
A list of metabolites significantly changing in the cinnamon/capsicum intervention study.
| Metabolite | Monoisotopic Mass * [Da] | RT [min] | Change [%] | VIP | Absolute p(corr) |
|---|---|---|---|---|---|
| Sphingosine-1-phosphate | 379.2489 | 5.0 | 170 | 1.26 | 0.49 |
| Sphinganine C17:0 | 287.282 | 4.2 | 1,758,409 | 2.11 | 0.88 |
| Arachidonic Acid methyl ester | 318.2559 | 8.0 | 688,141 | 1.32 | 0.58 |
| Docosenamide | 337.3343 | 7.4 | 159 | 2.43 | 0.99 |
| LPC 14:0 | 467.3007 | 5.1 | −27 | 1.13 | 0.48 |
| LPC 16:0 | 495.3328 | 5.5 | −100 | 1.52 | 0.64 |
| LPC 18:2 | 519.3327 | 5.4 | −8 | 1.79 | 0.79 |
| LPC 20:1 | 549.3789 | 6.3 | −34 | 1.50 | 0.67 |
| LPE P-16:0 | 437.2904 | 5.8 | −17 | 1.22 | 0.54 |
| LPE P-19:1 | 477.3213 | 5.7 | −29 | 2.01 | 0.87 |
| LPE 20:3 | 503.3013 | 5.6 | 1,134,744 | 1.36 | 0.56 |
| LPE 20:4 | 501.2858 | 5.3 | −52 | 1.35 | 0.38 |
| PC 32:4 | 757.5624 | 9.8 | −59 | 1.05 | 0.44 |
| PC36:2 | 807.5756 | 10.9 | −99 | 1.38 | 0.54 |
| PC 38:4 | 831.5747 | 10.2 | −99 | 1.32 | 0.53 |
| PC 40:6 | 855.5756 | 10.2 | −90 | 1.62 | 0.66 |
| PC 40:7 | 899.5623 | 10.5 | 2884 | 1.20 | 0.46 |
| PC 16:0/20:4 | 963.5415 | 9.6 | −88 | 1.50 | 0.42 |
| PC O-36:2 or PC P-36:1 | 771.6079 | 8.5 | 17,503 | 2.12 | 0.86 |
| PC O-40:5 or PC P-40:5 | 841.5964 | 10.2 | −100 | 1.72 | 0.69 |
| SM d34:2 | 846.4822 | 8.2 | −27 | 2.43 | 0.86 |
| SM d32:1 | 820.4666 | 8.0 | −30 | 2.35 | 0.78 |
Positive/negative value of percent of change means higher/lower AUC of postprandial change of metabolite level after cinnamon/capsicum capsule intake in comparison to placebo capsule intake. Metabolites significant after HC meal in OW/OB vs. NW comparisons are bolded. The p(corr) and VIP values were calculated based on the PLS-DA models. Variables with VIP > 1.0 and absolute p(corr) > 0.4 were considered significant. RT: retention time, p(corr): predictive loading value, VIP: variable importance into the projection, LPC: lysophosphatidylcholine, LPE: lysophosphoethanolamine, PC: phosphatidylcholine, PE: phosphoethanolamine, SM: sphingomyelin. * Measured monoisotopic neutral mass (list of ions is provided in the supplementary material).