. 2022 Oct 20;12(10):994. doi: 10.3390/metabo12100994

Table 3.

Studies reporting lipidomic LOX and CYP450_Ep pathway oxylipin measurements in circulation during lactation.

Study (First Author, Year)	Species	Sample Size	Oxylipin Pool	Oxylipin Classes Quantified	Sample Type	Study Oxylipin Outcomes
Johnson, 2022 [65]	Human	n = 10	Non-esterified	PGs LTs HETEs oxo-ETEs EpETrEs HEPEs DiHETEs SPMs	Plasma	Low plasma Vitamin A was associated with lower plasma concentrations of many oxylipins in lactating mothers.
Mavangira, 2015 [61]	Bovine	n = 24	Non-esterified	HODEs oxo-ODEs EpOMEs DiHOMEs PGs LTs HETEs EpETrEs DiHETrEs HDoHEs SPMs	Plasma	Multiple oxylipin classes had elevated concentrations in dairy cows with mastitis.
Kuhn, 2017 [63]	Bovine	n = 36	Non-esterified	HODEs EpOMEs DiHOMEs HETEs DiHETEs EpDPE SPMs	Plasma	20-HETE decreased and 9(10)-DiHOME increased from the periparturient to mid-lactation stage; 13-oxo-ODE decreased across the entire lactation.
Putman, 2019 [71]	Bovine	n = 10	Non-esterified	HODEs EpOMEs DiHOMEs HOTrEs PGs HETEs oxo-ETEs DiHETrEs DiHETEs HDoHEs EpDPEs DiHDPEs	Plasma	Many oxylipins spike in concentration around the time of dry-off and may be involved in the process of involution.
Olagaray, 2020 [72]	Ovine	n = 36	Non-esterified	HODEs oxo-ODEs EpOMEs DiHOMEs HOTrEs PGs TXs HETEs DiHETrEs HDoHEs EpDPEs DiHDPEs SPMs	Plasma	Treatment with meloxicam after birth reduced concentrations of some oxylipins, primarily 9(10)-DiHOME, in postpartum ewes.
King, 2021 [73]	Bovine	n = 30	Non-esterified	HODEs oxo-ODEs PGs LTs HETEs oxo-ETEs DiHETrEs HEPEs HDoHEs SPMs	Plasma Uterine flushing	Plasma oxylipins stay stable throughout early to late diestrous stage; Uterine oxylipins spike in late diestrous stage.

DiHDPEs—Dihydroxy docosapentaenoic acids; DiHETEs—Dihydroxy eicosatetraenoic acids; DiHETrEs—Dihydroxy eicosatrienoic acids; DiHOMEs—Dihydroxy octadecamonoenoic acids; EpDPEs—Epoxy docosapentaenoic acids; EpETrEs—Epoxy eicosatrienoic acids; EpOMEs—Epoxy octadecamonoenoic acids; HDoHEs—Hydroxy docosahexaenoic acids; HEPEs—Hydroxy eicosapentaenoic acids; HETEs—Hydroxy eicosatetraenoic acids; HODEs—Hydroxy octadecadienoic acids; HOTrEs—Hydroxy octadecatrienoic acids; LTs—Leukotrienes; oxo-ETEs—Oxo eicosatetraenoic acids; oxo-ODEs—Oxo octadecadienoic acid; PGs—Prostaglandins; SPMs—Specialized pro-resolving lipid mediators; TXs—Thromboxanes.