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. 2022 Oct 20;10(10):1756. doi: 10.3390/vaccines10101756

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Overactivation of NETosis-related proteins in A. phagocytophilum-infected human cells. (A) Protein interactions network between proteins that are significantly different in human cell proteomics analysis. The color of each nod is based on Log2 fold change, and edge mapping width is based on protein interaction score: min = 0.2, max = 1.00. (B1) Eleven different ontology terms have been used for the go study. (B2) GO data shows that proteins are involved in the ‘innate immune system’, ‘response to stress’, and ‘lipopolysaccharide-mediated signaling pathway’ are significant triggers in the network. (B3) Reactome data shows the association of the ‘innate immune system’ and ‘neutrophil degranulation’ pathways in our data. (C) String network shows a protein-protein interaction implied in NETosis.